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Up-regulation of TGF-beta1 mRNA expression in peripheral blood mononuclear cells of patients with chronic fatigue syndrome - Source: Journal of the Formosan Medical Association, Nov 2011

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By HY Zhang, et al. • • December 1, 2011

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[Note: TGF-beta1 stands for “transforming growth factor beta” type 1. It is a protein secreted by most immune cells (leukocytes) and plays an important role in controlling the immune system. Its effect differs depending on the type of cell involved, and at different cellular developmental stages (e.g.,  growth, multiplication, differentiation, cell death).]

Background/Purpose: It has been shown that the abnormality in immune cells in chronic fatigue syndrome (CFS) patients is closely associated with the participation of TGF-beta.

In order to study the relationship between TGF-beta1 and CFS, we investigated the mRNA levels of TGF-beta1 in peripheral blood mononuclear cells (PBMCs) in patients with CFS.

Methods: Fluorescent quantitative real time reverse-transcription polymerase chain reaction (FQ-RT-PCR) was performed to test TGF-beta1 mRNA expression in PBMCs in 63 cases of CFS, 50 cases of disease controls, and 50 cases of healthy controls.

Results: The mean value of TGF-beta1 mRNA expression in CFS patients was deltadeltaCt=1.17±0.58, which was significantly higher than the disease controls (deltadeltaCt=0.07±1.08, df=111, p < 0.01) and the healthy controls (deltadeltaCt=0.00±1.63, df=111, p < 0.01). No significant difference was detected between disease and healthy controls (p > 0.05).

Conclusion: The expression of TGF-beta1 in peripheral blood mononuclear cells is significantly elevated in patients with CFS. It might be correlated to the pathogenesis of the disease.

Source: Journal of the Formosan Medical Association, Nov 2011;110(11):701-4. PMID:22118314, by Zhang HY, Liu ZD, Hu CJ, Wang DX, Zhang YB, Li YZ. Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.

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