ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

CDC Whistleblower Reveals Widespread Manipulation of Scientific Data and Top-Down Pressure on CDC Sc...

Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel

How Glutathione Can Save Your Life

9 Health Benefits of Cucumbers

Coenzyme Q10 Benefits Symptoms in Gulf War Veterans: Results of a Randomized Double-Blind Study

Brain inflammation dramatically disrupts memory retrieval networks, UCI study finds

VIDEO: Relaxation - Ocean Voyager Part I

Clinical trial demonstrates safety, effectiveness of immunotherapy for AdV, BKV, and herpesviruses i...

Scientists discover how to 'switch off' autoimmune diseases

New estrogen-based compound suppresses binge-like eating behavior in female mice

 
Print Page
Email Article

Up-regulation of TGF-beta1 mRNA expression in peripheral blood mononuclear cells of patients with chronic fatigue syndrome - Source: Journal of the Formosan Medical Association, Nov 2011

  [ 20 votes ]   [ Discuss This Article ]
By HY Zhang, et al. • www.ProHealth.com • December 1, 2011


[Note: TGF-beta1 stands for “transforming growth factor beta” type 1. It is a protein secreted by most immune cells (leukocytes) and plays an important role in controlling the immune system. Its effect differs depending on the type of cell involved, and at different cellular developmental stages (e.g.,  growth, multiplication, differentiation, cell death).]

Background/Purpose: It has been shown that the abnormality in immune cells in chronic fatigue syndrome (CFS) patients is closely associated with the participation of TGF-beta.

In order to study the relationship between TGF-beta1 and CFS, we investigated the mRNA levels of TGF-beta1 in peripheral blood mononuclear cells (PBMCs) in patients with CFS.

Methods: Fluorescent quantitative real time reverse-transcription polymerase chain reaction (FQ-RT-PCR) was performed to test TGF-beta1 mRNA expression in PBMCs in 63 cases of CFS, 50 cases of disease controls, and 50 cases of healthy controls.

Results: The mean value of TGF-beta1 mRNA expression in CFS patients was deltadeltaCt=1.17±0.58, which was significantly higher than the disease controls (deltadeltaCt=0.07±1.08, df=111, p < 0.01) and the healthy controls (deltadeltaCt=0.00±1.63, df=111, p < 0.01). No significant difference was detected between disease and healthy controls (p > 0.05).

Conclusion: The expression of TGF-beta1 in peripheral blood mononuclear cells is significantly elevated in patients with CFS. It might be correlated to the pathogenesis of the disease.

Source: Journal of the Formosan Medical Association, Nov 2011;110(11):701-4. PMID:22118314, by Zhang HY, Liu ZD, Hu CJ, Wang DX, Zhang YB, Li YZ. Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid

Natural Remedies

Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing