ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Higher dementia risk linked to more use of common drugs

Top Anti-Inflammatory Foods, Herbs, and Spices

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

Latent HIV may lurk in 'quiet' immune cells, research suggests

Multiple sclerosis: pathological progression of the disease documented for the first time

Propolis - The Natural Antibiotic for MRSA, Candida, and More

Activate Your Natural Killer Cells

Microbiome linked to type 1 diabetes

Baylor Scientist Finds First Direct Evidence of Gene-Exposure Link in Gulf War Illness

Lyme disease costs up to $1. 3 billion per year to treat, study finds

 
Print Page
Email Article

Up-regulation of TGF-beta1 mRNA expression in peripheral blood mononuclear cells of patients with chronic fatigue syndrome - Source: Journal of the Formosan Medical Association, Nov 2011

  [ 20 votes ]   [ Discuss This Article ]
By HY Zhang, et al. • www.ProHealth.com • December 1, 2011


[Note: TGF-beta1 stands for “transforming growth factor beta” type 1. It is a protein secreted by most immune cells (leukocytes) and plays an important role in controlling the immune system. Its effect differs depending on the type of cell involved, and at different cellular developmental stages (e.g.,  growth, multiplication, differentiation, cell death).]

Background/Purpose: It has been shown that the abnormality in immune cells in chronic fatigue syndrome (CFS) patients is closely associated with the participation of TGF-beta.

In order to study the relationship between TGF-beta1 and CFS, we investigated the mRNA levels of TGF-beta1 in peripheral blood mononuclear cells (PBMCs) in patients with CFS.

Methods: Fluorescent quantitative real time reverse-transcription polymerase chain reaction (FQ-RT-PCR) was performed to test TGF-beta1 mRNA expression in PBMCs in 63 cases of CFS, 50 cases of disease controls, and 50 cases of healthy controls.

Results: The mean value of TGF-beta1 mRNA expression in CFS patients was deltadeltaCt=1.17±0.58, which was significantly higher than the disease controls (deltadeltaCt=0.07±1.08, df=111, p < 0.01) and the healthy controls (deltadeltaCt=0.00±1.63, df=111, p < 0.01). No significant difference was detected between disease and healthy controls (p > 0.05).

Conclusion: The expression of TGF-beta1 in peripheral blood mononuclear cells is significantly elevated in patients with CFS. It might be correlated to the pathogenesis of the disease.

Source: Journal of the Formosan Medical Association, Nov 2011;110(11):701-4. PMID:22118314, by Zhang HY, Liu ZD, Hu CJ, Wang DX, Zhang YB, Li YZ. Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid

Natural Remedies

Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Broad Spectrum Protection Against Brain Aging Broad Spectrum Protection Against Brain Aging
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing