Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Decreased levels of vitamin D associated with reduced methylation in African American teens

Sweep Away Senile Cells

PAIN'S SECRET MESSAGE: Why Prince Didn't Need to Die

8 Hacks to Slash Medication Costs

7 Natural Ways to Prevent Diabetes

New Study Shows Optimized Curcumin Stops Inflammation

Relief from Common Digestive Distress

What Foods Can Help Fight the Risk of Chronic Inflammation?

Block The Vascular Origins Of Cognitive Decline

SURVEY: Should Opioids Be Restricted for Chronic Illness?

 
Print Page
Email Article

Zurich studies suggest muscle fatigue signals, like disordered pain signals, start in brain

  [ 18 votes ]   [ 1 Comment ]
www.ProHealth.com • December 5, 2011


Based on these studies, it will be possible to specifically investigate reasons for reduced muscular performance without apparent cause – as in certain cases diagnosed as chronic fatigue syndrome.

The extent to which we are able to activate our muscles can depend on motivation, physical condition/muscle fatigue, and the perception of muscle fatigue.

For a long time, the research on muscle fatigue was largely confined to changes in the muscle itself. Now, a Swiss research project has shifted the focus to brain research - with significant implications not just for optimizing physical performance but for the investigation of reasons for reduced muscular performance related, for example, to certain medications and various diseases.

Headed by neuro-psychologist Kai Lutz (University of Zurich) in collaboration with Prof Urs Boutellier (Institute of Human Movement Sciences & Sport at ETH Zurich), the researchers discovered neuronal processes for the first time that are responsible for reducing muscle activity during muscle-fatiguing exercise.

The third and final part of this series of experiments has now been published in the European Journal of Neuroscience.

Muscle's nerve impulses inhibit motoric area in the brain

In the initial study(1), the researchers showed that nerve impulses from the muscle - much like pain information - inhibit the primary motoric area during a tiring, energy-demanding exercise.

They were able to prove this using measurements in which study participants repeated thigh contractions until they could no longer attain the force required.

If the same exercise was conducted under narcotization of the spinal chord (spinal anesthesia), thus interrupting the response from the muscle to the primary motoric area, the corresponding fatigue-related inhibition processes became significantly weaker than when the muscle information was intact.

Other brain areas analyze nerve signals

In a second step, using functional magnetic resonance imaging, the researchers were able to localize the brain regions that exhibit an increase in activity shortly before the interruption of a tiring, energy-demanding activity and are thus involved in signalizing the interruption.(2)

These brain areas are the thalamus and the insular cortex – both areas which analyze information that indicates a threat to the organism, such as pain or hunger.

Insular cortex regulates message to motoric area

The third study has now shown that the inhibitory influences on motoric activity are actually mediated via the insular cortex.(3)

In tests using a bicycle ergometer, the researchers determined that the communication between the insular cortex and the primary motoric area became more intensive as the fatigue progressed.

"This can be regarded as evidence that the neuronal system found not only informs the brain, but also actually has a regulating effect on motoric activity," explains University of Zurich researcher Lea Hilty, who conducted the experiment as part of her doctoral thesis.

And the results open up a new research field, says Dr. Lutz

"The findings are an important step in discovering the role the brain plays in muscle fatigue," he says. "Based on these studies, it won't just be possible to develop strategies to optimize muscular performance, but also specifically investigate reasons for reduced muscular performance in various diseases."

• Prolonged reduced physical performance is a symptom that is frequently observed in daily clinical practice.

• It can also appear as a side effect of certain medication.

• However, so-called chronic fatigue syndrome is often diagnosed without any apparent cause.

References:

1. “Limitation of Physical Performance in a Muscle Fatiguing Handgrip Exercise Is Mediated by Thalamo-Insular Activity.” Human Brain Mapping, Dec 10, 2010. Lea Hilty, Lutz Jäncke, Roger Luechinger, Urs Boutellier, Kai Lutz.

2. “Spinal opioid receptor-sensitive muscle afferents contribute to the fatigue-induced increase in intracortical inhibition in healthy humans.” Experimental Physiology, Feb 11, 2011. Lea Hilty, Kai Lutz, Konrad Maurer, Tobias Rodenkirch, Christina M. Spengler, Urs Boutellier, Lutz Jäncke, Markus Amann.

3. “Fatigue-induced increase in intracortical communication between mid ?anterior insular and motor cortex during cycling exercise.” European Journal of Neuroscience, Nov 21, 2011. Lea Hilty, Nicolas Langer, Roberto Pascual-Marqui, Urs Boutellier, Kai Lutz.

Source: Based on University of Zurich Press Release, Dec 5, 2011




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

Zurifh studies suggest muscle fatigue signals.......
Posted by: ppmickey@gmail.com
Dec 7, 2011
So are you saying that CFS is a wastebasket diagnosis when doctors don't know what else to call what we have? It sounds like you are a dubious believer of the condition as well. At least that's how I see it. Maybe my impaired brain function from CFS made me misunderstand what you wrote. Who knows?
Reply Reply
 
20 Helpful Tips for Cleaning and Organizing When You're Chronically Ill

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Health Benefits Are Brewing in Green Tea Health Benefits Are Brewing in Green Tea
Clinically Studied Joint Relief Product for FM & ME/CFS Clinically Studied Joint Relief Product for FM & ME/CFS
Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler

· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map