ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Vitamin D Deficiency Linked to Neurological Diseases; Also Raises Risk of Asthma Attacks, and More

7 Best Foods You Can Eat

Study: Doubling saturated fat in the diet does not increase saturated fat in blood

The Gut Microbiome and the Brain

Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed

CoQ10 supplementation reduces statin-related muscle pain in randomized trial

Controlling obesity with potato extract

Plant used in traditional Chinese medicine may treat metabolic diseases and obesity

Natural Gut Viruses Join Bacterial “Cousins” in Maintaining Health and Fighting Infections

Proton pump inhibitors decrease diversity in gut microbiome, increase risk for complications

 
Print Page
Email Article

Blood test good predictor of response to SSRI antidepressant / anxiety drug

  [ 15 votes ]   [ 1 Comment ]
www.ProHealth.com • December 16, 2011


Potentially a big step toward ability to hit it right with the first prescription and avoid the often lengthy Rx trial & error process
 
Loyola University Medical Center researchers believe they’ve identified the first reliable method for predicting whether a specific antidepressant will help a depressed patient. (Antidepressant prescription tends to be a trial and error process, since different people are helped by different drugs, and nobody really knows why.)

The researchers found that blood tests for a protein called vascular endothelial growth factor (VEGF) largely separated out those depressed patients likely to respond well to the SSRI drug escitalopram (brand name Lexapro®) and who would not. Of 35 patients with major depression who were treated with escitalopram:

• More than 85% of those with higher than normal blood levels of VEGF experienced partial or complete relief from depression after taking escitalopram.

• By comparison, fewer than 10% of those who had low levels of VEGF responded to the drug.

Since currently 60% of depression patients will not respond well to the first drug prescribed and it can take a month to achieve a drug response, such strategies promise a considerable improvment in time to benefit.

SSRIs - selective serotonin reuptake inhibitors - are a class of drugs that support an increase of serotonin levels in the brain. Other common SSRIs are Prozac®, Paxil® and Zoloft®. VEGF is a signal protein that cells produce to encourage vessel growth when they sense blood circulation/oxygen supply is inadequate.

"This would be the first time we would have a predictor for how well a patient would respond to an antidepressant," says Loyola neuroscientist Angelos Halaris, MD, PhD, who presented the study at the 2011 Society of Biological Psychiatry and Illinois Brain, Behavior & Immunity annual meetings. "It would greatly benefit our patients if we could predict ahead of time whether a given medication would be effective for a certain patient."

How Might VEGF Support SSRI Effectiveness?
Scientists aren't certain why SSRIs work in some patients but not in others. One possible mechanism is that SSRIs help restore a chemical balance in the brain.

Some scientists recently have proposed a second possible mechanism, called neurogenesis – that SSRIs help to regenerate brain cells in specific parts of the brain that have atrophied in depressed patients. The Loyola study supports the neurogenesis theory.

It appears that escitalopram, the SSRI used in the Loyola study, jump-starts brain cells that have become inactive. This regeneration is fueled by VEGF's ability to stimulate vessel growth and other activities that keep brain cells healthy and active.

It appears that in patients with higher levels of VEGF, there was more regeneration, helping to reduce depression. Conversely, in patients with lower VEGF levels, there was less regeneration of brain cells and less relief from depression.

Next Steps
If the finding is confirmed by further studies, it could lead to a blood test that would help physicians tailor treatment. If, for example, a patient had low levels of VEGF, the physician might skip SSRIs and try alternative classes of antidepressants, such as bupropion, or alternative therapies, such as psychotherapy or Transcranial Magnetic Stimulation (TMG).

Testing Cost
Though the VEGF test is currently ‘expensive’ - nearly $300 at one leading lab – Dr. Halaris suggests the cost likely would come down significantly if it were to become widely used. (And patient benefit in time to therapeutic relief would presumably be a major consideration.)

Source: Based on Loyola University Medical Center news release, Dec 15, 2010



Please Discuss This Article:   Post a Comment 

Since different People are 'Helped' by "Different-Drugs", and "Nobody-Really-Knows-Why? ...'I-Do'!
Posted by: steweeme
Dec 17, 2011
'Hello': Isn't about time WE get these, 'Psycho-Psychiatrists' on the 'Streight' & 'Narrow'? It's called "DOUBLE-SPEAK"! ...'LADIES' & 'GENTLEMAN', the time is 'NOW' to 'ADDRESS' ...'C-A-F-F-E-I-N-E' for the 'MAJOR-HEALTH-ISSUES' of the Day! 'Listen' to all the 'BOILER-PLATE' ...'Sprewed-Throughout-the-Article'? 'ANTI-DEPRESSANTS'? Would YOU 'Believe' that 'IF-YOU-GO-UP', you 'MUST-COME-DOWN'? (and 'NOBODY' like to go 'DOWN'!) Well then, lets just 'PASS-OUT-ANTIDEPRESSANTS' like 'CRAZY', and make 'NO-MENTION' of 'ABSOLUTELY-ADDICTING', *NERVE-WRACKING*, 'DESTRUCTIVE-CAFFEINE'? (something 'WRONG' with this 'Picture'?) 'N-E-V-E-R' will the 'Psycho-Psychiatrists' 'ADDRESS-CAFFEINE'! ...'Obesity'? 'Diabetes'? 'Migraines'? 'Alzheimers'? 'School-Masacures'? 'Ritalin-Addiction'? 'Smoking-to-Death'? etc.! *Please-Visit* my Web-Site: www.AddictedMAN.com, and 'See-Me' in Action at, YouTube.com: AddictedMAN w/Steweeme
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health

Natural Remedies

Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Broad Spectrum Protection Against Brain Aging Broad Spectrum Protection Against Brain Aging
Protecting Our Eyes Against Time-Induced Damage Protecting Our Eyes Against Time-Induced Damage

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing