Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging
– Source: Neurology, Jan 24, 2012
By GL Bowman, et al.
Objective: To examine the cross-sectional relationship between nutrient status and psychometric and imaging indices of brain health in dementia-free elders.
Methods: Thirty plasma biomarkers of diet were assayed in the Oregon Brain Aging Study cohort (n = 104). Principal component analysis constructed nutrient biomarker patterns (NBPs) and regression models assessed the relationship of these with cognitive and MRI outcomes.
Results: Mean age was 87 ± 10 years and 62% of subjects were female.
Two nutrient biomarker patterns associated with more favorable cognitive and MRI measures:
• One high in plasma vitamins B (B1, B2, B6, folate, and B12), C, D, and E,
• And another high in plasma marine omega-3 fatty acids [fish oil].
• A third pattern characterized by high trans fat was associated with less favorable cognitive function and less total cerebral brain volume.
• Depression attenuated the relationship between the marine omega-3 pattern and white matter hyperintensity volume.
Conclusion: Distinct nutrient biomarker patterns detected in plasma are interpretable and account for a significant degree of variance in both cognitive function and brain volume.
Objective and multivariate approaches to the study of nutrition in brain health warrant further study. These findings should be confirmed in a separate population
Source: Neurology, Jan 24, 2012. Bowman GL, Silbert LC, Howieson D, Dodge HH, Traber MG, Frei B, Kaye JA, Shannon J, Quinn JF. Oregon Health & Science University, Portland, Oregon; Portland VA Medical Center and Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA. [Email: firstname.lastname@example.org]