ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial

Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep?

Exploring the association between Morgellons disease and Lyme disease: identification of Borrelia bu...

Lyme Disease Activists Take Fight to Washington D.C.

New Envita Study Shows Chronic Lyme Disease "Fools" Immune System, Resistant to Antibiotics

Safely Burn Away Body Fat

Omega-3 fatty acids boost B vitamin brain benefit

Substantial health threat: Never-before-seen tick-borne disease

Lyme Advocates Call on IDSA to Focus on Patient Care Instead of Attacking Those in Distress

Trigger identified that likely unleashes autoimmune disease

 
Print Page
Email Article

Search for Gene-Altering Triggers in Chronic Fatigue Syndrome Heats Up at U Toronto

  [ 53 votes ]   [ 2 Comments ]
www.ProHealth.com • February 24, 2012


 Epigenetics is the study of changes in a gene’s ‘expression’ - and of the factors that trigger those changes. University of Toronto epigeneticist Patrick O McGowan, PhD, is actively studying the epigenetics of chronic fatigue syndrome – whether, when, how, to what extent, and in what circumstances the expression of certain genes may determine susceptibility to or drive ME/CFS.

Specifically, Dr. McGowan is examining how environmental triggers might alter gene expression so as to alter immune function and stress response in ways that contribute to ME/CFS.

• Epigenetic changes in gene function don’t change the gene itself - the underlying DNA sequence.

• They’re more a case of possible activities being turned on or turned off.

• Epigenetic changes can be caused by environmental triggers, which can include factors such as infections, toxins, stress, nutrition, and even the social environment.

• The question being, how much of the patient’s gene expression is explained by inherited DNA, and how much by effects of the environment?

Dr. McGowan will conduct his study of the epigenetics of ME/CFS with a grant from the CFIDS Association of America. As part of the grant, he will have access to the SolveCFS Biobank, a collection of biological samples from ME/CFS patients.

Looking for Clues in Banked ME/CFS Blood & Tissue Samples

Specifically, Dr. McGowan will look at the relationship between a system called the hypothalamic-pituitary-adrenal (HPA) axis and immune function.

The HPA axis is involved in the regulation of the stress response, and has effects on immune activity and inflammation through cellular signaling mechanisms involving the steroid glucocorticoid.

Glucocorticoid (cortisol is a glucocorticoid) in fact has a “huge number” of physiological influences, including glucose concentration in the blood, cognitive function, and sleep cycles. Essentially every cell in the body has glucocorticoid receptors. 

Dr. McGowan's hypothesis is that there is an epigenetic mechanism in CFS that disrupts glucocorticoid signaling in white blood cells called lymphocytes, which are responsible for immune responses.

By studying tissue samples from the SolveCFS Biobank he hopes to pinpoint the mechanism. This repository of tissue and blood samples is part of the Genetic Alliance Registry and BioBank.

Dr. McGowan’s previous investigations have involved for example the effects on epigenetic expression of inadequate methyl-related nutrients in the diet (e.g., folate, methionine, B12 and B6), fetal nutritional restriction, maternal behavior, social adversity, and fear/abuse-related stress.

ME/CFS, or “CFIDS” (Chronic Fatigue and Immune Dysfunction Syndrome) is a complex and debilitating chronic illness that affects the brain and multiple body systems. Symptoms include incapacitating fatigue and problems with concentration and short-term memory. Millions of North Americans are thought to suffer from the disease.

Source: Based on University of Toronto, Scarborough news release, Feb 23, 2012



Please Discuss This Article:   Post a Comment 

more psychosocial research into mecfs is NOT needed
Posted by: oerganix
Feb 25, 2012
This looks like an extension of the CDC's attempt to blame this illness on childhood abuse and "bad mothering." The basis of determining changes to the brain and the immune system because of "abuse" is very shakey and doesn't stand up to rigorous scientific examination, although it has become a popular way of attracting grant money to "study" the "mind-body connection."
Reply Reply

CFS Biobank
Posted by: jacobs27
Feb 25, 2012
I'm very concerned that using the CFS biobank could be a problem here. The CFIDS association has never had a real problem with the CDC criteria for CFS. In fact there head of research Suzanne Vernon is one of it's creators.
If they are using a diluted patient pool for samples in which some patients have a NueroImmune diseas and some actually have MDD or other disorders all results from studies such as these will be weakened in the least and may actually turn out to be harmful.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
SAD? Coping with Seasonal Affective Disorder

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing