Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

How Good Fats Prevent Heart Disease

Anti-inflammatory "No More Aches and Pains" Smoothie Bowl

The Bees' Best-Kept Secret: The Amazing Health Benefits of Propolis

Acupuncture: Why It Works

For women, healthy diets may help with mobility when aging

The Relationship Between Vitamin D and Insulin Resistance

8 Things to Consider for Depression

VIDEO: Living with Chronic Pain

ACTION ALERT: Improve US chronic pain care

Supplements Proven Beneficial for Depression

 
Print Page
Email Article

More evidence that acetyl-L-carnitine may promote brain & cognitive health

  [ 20 votes ]   [ Discuss This Article ]
By M Malaguarnera • www.ProHealth.com • February 27, 2012


Article:
Carnitine Derivatives: Clinical Usefulness
- Source: Current Opinion in Gastroenterology, Mar 2012

By M Malaguarnera

[Note: For more information relating to chronic fatigue syndrome and fibromyalgia, see also "Breaking Through the Mental Fog," and "L-Carnitine: Typically Low in Fibromyalgia and ME/CFS; Promotes Healthy Mood & Energy".]

Abstract:
Purpose of Review: Carnitine [L-Carnitine] and its derivatives are natural substances involved in both carbohydrate and lipid metabolism.

This review summarizes the recent progress in the field in relation to the molecular mechanisms.

Recent Findings: The pool of different carnitine derivatives is formed by acetyl-L-carnitine (ALC), propionyl-L-carnitine (PLC), and isovaleryl-carnitine.

Acetyl-L-carnitine may have a preferential effect on the brain tissue.

Acetyl-L-carnitine represents a compound of great interest for its wide clinical application in various neurological disorders: It may be of benefit in treating:

• Alzheimer's dementia,

• Depression in the elderly,

• HIV infection,

• Chronic fatigue syndrome [ME/CFS],

• Peripheral neuropathies,

• Ischemia [reduced blood flow] and reperfusion of the brain,

• And cognitive impairment associated with various conditions.

Propionyl-L-carnitine (PLC) has been demonstrated to replenish the intermediates of the tricarboxylic acid cycle by the propionyl-CoA moiety, a greater affinity for the sarcolemmal carrier, peripheral vasodilator activity, a greater positive inotropism, and more rapid entry into myocytes. [Note: The complex tricarboxylic acid cycle - aka Krebs cycle or citric acid cycle - involves breakdown of fatty acids, carbs and proteins in the mitochondria to produce cellular energy (ATP).]

Most studies of the therapeutic use of PLC are focused on the prevention and treatment of:

• Ischemic heart disease [heart can’t pump enough blood to rest of body owing to narrowing of small blood vessels supplying the heart],

• Congestive heart failure [heart muscle weakened by narrowed arteries/reduced blood supply],

• Hypertrophilic heart disease [heart muscle thickening],

• And peripheral arterial disease [plaque buildup reduces blood flow to arms & legs].

Acetyl-L-carnitine and propionyl-L-carnitine are considered well tolerated without significant side-effects.

Summary: A number of therapeutic effects possibly come from the interaction of carnitine and its derivatives with the elements of cellular membranes.

Source: Current Opinion in Gastroenterology, Mar 2012;28(2) pp166-176. PMID: 22333562, by Malaguarnera M. Research Centre 'The Great Senescence', University of Catania, Catania, Italy.




Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Acetyl L-Carnitine HCL Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Fibro Energy Formula™ Fibro Energy Formula™
13 Top Nutrients for Effective Energy Support
Acetyl L-Carnitine HCL Acetyl L-Carnitine HCL
Sharpen Mental Focus & Concentration
Acetyl L-Carnitine + Alpha Lipoic Acid Acetyl L-Carnitine + Alpha Lipoic Acid
Enhancement of antioxidants, better conversion of food to energy
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Magnesium: An Essential Supplement for ME/CFS Magnesium: An Essential Supplement for ME/CFS

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map