ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Vitamin D Deficiency Linked to Neurological Diseases; Also Raises Risk of Asthma Attacks, and More

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

7 Best Foods You Can Eat

Study: Doubling saturated fat in the diet does not increase saturated fat in blood

The Gut Microbiome and the Brain

Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed

CoQ10 supplementation reduces statin-related muscle pain in randomized trial

Controlling obesity with potato extract

Plant used in traditional Chinese medicine may treat metabolic diseases and obesity

Natural Gut Viruses Join Bacterial “Cousins” in Maintaining Health and Fighting Infections

 
Print Page
Email Article

Larger study adds to evidence linking leaky gut, immune response, and chronic depression

  [ 8 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 17, 2012


Article:
Increased IgA and IgM responses against gut commensals in chronic depression: Further evidence for increased bacterial translocation or leaky gut
- Source: Journal of Affective Disorders, Mar 11, 2012

By Michael Maes, et al.

[Note: Commensals are bacteria that may live peacefully on or in the body (e.g., in the gut but not in the blood stream). IgM antibodies are found in blood and lymph fluid; IgA antibodies protect body surfaces exposed to foreign substances, e.g., gut lining, membrane in nose.]

Abstract:
Background: Recently, we discovered that depression is accompanied by increased IgM and IgA responses directed against gram negative gut commensals. [See also their recent report finding this association in chronic fatigue syndrome (ME/CFS) patients.]

The aim of this study was to replicate these findings in a larger study group of depressed patients and to examine the associations between the IgA and IgM responses to gut commensals and staging of depression as well as the fatigue and somatic (F&S) symptoms of depression.

Methods: We measured serum concentrations of IgM and IgA against the LPS [lipopolysaccarides, found in the cell walls] of gram-negative enterobacteria, i.e., Hafnia alvei, Pseudomonas aeruginosa, Morganella morganii, Pseudomonas putida, Citrobacter koseri, and Klebsiella pneumoniae in 112 depressed patients and 28 normal controls.

The severity of fatigue and somatic symptoms was measured using the Fibromyalgia and Chronic Fatigue Syndrome Rating Scale.

Results:

• The prevalences and median values of serum IgM and IgA against LPS of these commensals were significantly higher in depressed patients than in controls.

• The IgM levels directed against the LPS of these commensal bacteria were significantly higher in patients with chronic depression than in those without.

• The immune responses directed against LPS were not associated with melancholia or recurrent depression.

• There was a significant correlation between the IgA response directed against LPS and gastro-intestinal symptoms.

Discussion: The results indicate that increased bacterial translocation with immune responses to the LPS of commensal bacteria may play a role in the pathophysiology of depression, particularly chronic depression.

Bacterial translocation may:

a)    Occur secondary to systemic inflammation in depression and intensify and perpetuate the primary inflammatory response once the commensals are translocated; or

b)    Be a primary trigger factor associated with the onset of depression in some vulnerable individuals.

The findings suggest that “translocated” gut commensal bacteria activate immune cells to elicit IgA and IgM responses and that this phenomenon may play a role in the pathophysiology of (chronic) depression by causing progressive amplifications of immune pathways.

Source: Journal of Affective Disorders, Mar 11, 2012. Maes M, Kubera M, Leunis JC, Berk M. Maes Clinics, Tria, Bangkok, Thailand; Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland; Laboratory Ategis, Waver, Belgium; Mental Health Research Institute, Parkville, Australia; Deakin University, School of Medicine, Barwon Health, Geelong, Australia; University of Melbourne, Department of Psychiatry, Parkville, Australia; Orygen Youth Health Research Centre, Parkville, Australia. [Email: dr.michaelmaes@hotmail.com]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing