Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Big step towards cure for HIV and other lifelong viral infections

SURVEY RESULTS: Attitudes About Fatigue

Superfood Trio: Ginger, Turmeric, and Carrots?

Rejuvenate Your Skin Naturally With Sea Buckthorn Oil

Can Drinking More Water Help You Lose Weight?

Resveratrol’s Link to Slowing Alzheimer’s

Tropical Turmeric Carrot Juice & Smoothie

Most Everyone Can Use More Vitamin D

Greater intake of dietary omega-3 fatty acids associated with lower risk of diabetic retinopathy

Omega-3s May Improve Healing After a Heart Attack

 
Print Page
Email Article

Oxidative stress linked to headache in fibromyalgia; CoQ10 supports important improvement

  [ 17 votes ]   [ 1 Comment ]
www.ProHealth.com • April 22, 2012


Article:
Oxidative Stress Correlates with Headache Symptoms in Fibromyalgia: Coenzyme Q10 Effect on Clinical Improvement
– Source: PLoS One, Apr 19, 2012

By Mario D Cordero, et al.

[Note: The full text of this very important article is available free HERE. Oxidative stress is damage done to the fatty acids comprising cell membranes (like rust in a tin can) by unpaired electrons called free radicals, produced in excess of what the cells’ natural antioxidative processes can neutralize. Coenzyme Q10 and catalase are naturally occurring antioxidants. The study first compared measures of mitochondrial ATP production, oxidative stress, antioxidants and symptoms in FM patients vs healthy controls, then took measures of FM patients after supplementation with 300mg of CoQ10 [ubiquinone form] daily for 3 months. They conclude by stating: “Headache symptoms in FM could be a consequence of oxidative stress and both may share common pathophysiologic basis. Furthermore, CoQ10 treatment showed a remarkable improvement in clinical symptoms and headache in FM.”]

Abstract:
Background: Fibromyalgia (FM) is a chronic pain syndrome with unknown etiology and a wide spectrum of symptoms such as allodynia, debilitating fatigue, joint stiffness and migraine.

Recent studies have shown some evidences demonstrating that oxidative stress is associated to clinical symptoms in FM of fibromyalgia.

• We examined oxidative stress and bioenergetic status in blood mononuclear cells (BMCs) and its association to headache symptoms in FM patients.

• The effects of oral coenzyme Q10 (CoQ10) supplementation on biochemical markers and clinical improvement were also evaluated.

Methods: We studied 20 FM patients and 15 healthy controls. Clinical parameters were evaluated using the Fibromyalgia Impact Questionnaire (FIQ), visual analogues scales (VAS), and the Headache Impact Test (HIT-6).

Oxidative stress was determined by measuring CoQ10, catalase and lipid peroxidation (LPO) levels in BMCs. Bioenergetic status was assessed by measuring ATP levels in BMCs. [Lipid peroxidation is the degradation of fatty acids in cell membranes caused by oxidative stress. ATP is the fuel that the mitochondria burn to produce cellular energy.]

Results:

• We found decreased CoQ10, catalase and ATP levels in BMCs from FM patients as compared to normal controls (P<0.05 and P<0.001, respectively)

• We also found increased level of LPO in BMCs from FM patients as compared to normal control (P<0.001).

• Significant negative correlations between CoQ10 or catalase levels in BMCs and headache parameters were observed (r = -0.59, P<0.05; r = -0.68, P<0.05, respectively). [Less CoQ10 or catalase, more severe headache, and vice-versa.] Furthermore, LPO levels showed a significant positive correlation with HIT-6 (r = 0.33, P<0.05). [HIT-6 is a Headache Impact Test.]

Oral CoQ10 supplementation restored biochemical parameters and induced a significant improvement in clinical and headache symptoms (P<0.001). [Bolding added. Ten of the FM patients were supplemented with 300 mg/day of CoQ10 [ubiquinone] divided in three doses, for three months.]

Discussion:

• The results of this study suggest a role for mitochondrial dysfunction and oxidative stress in the headache symptoms associated with FM.

• CoQ10 supplementation should be examined in a larger placebo controlled trial as a possible treatment in FM.

Source: PloS ONE, Apr 19, 2012;7(4). DOI:10.1371/journal.pone.0035677, by Cordero MD, Cano-García FJ, Alcocer-Gómez E, De Miguel M, Sánchez-Alcázar JA.  Centro Andaluz de Biologia del Desarrollo (CABD), Universidad Pablo de Olavide-CSIC-Junta de Andaluc?a and Centro de Investigacion Biomedica en Red de Enfermedades Raras, Sevilla, Spain.





Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength FibroSleep™ Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

Heart Condition
Posted by: imvalerie
May 15, 2012
Aside from Fibromyalgia, my doctor also mentioned that CoQ10 can also help boost your heart health. This is the reason why my dad is now taking this as his doctor recommends. He's been taking it for 5 months now and so far, he is in good condition. But of course, I make sure he never forget to eat proper diet and have his daily exercise.
Reply Reply
 
Natural Pain Relief Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
Thyroid Health and Fibromyalgia Thyroid Health and Fibromyalgia

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map