The Neuroprotective Role of Omega-3 Fatty Acids & Potential Significance for Alzheimer's
May 16, 2012
Effects of DHA-Rich Omega-3 Fatty Acid Supplementation on Gene Expression in Blood Mononuclear Leukocytes: The OmegAD Study
- Source: PLoS ONE, Apr 24, 2012
By Inger vedin, et al.
[Note: to review the full text of this open-access article free, click HERE and scroll down.]
Background: Dietary fish oil, rich in omega-3 fatty acids (n-3 FAs) - e.g. docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) - regulate inflammatory reactions by various mechanisms, e.g. gene activation.
However, the effects of long-term treatment with DHA and EPA in humans, using genome wide techniques, are poorly described.
Hence, our aim was to determine the effects of 6 months of dietary supplementation with an n-3 FA preparation rich in DHA on global gene expression in peripheral blood mononuclear cells.
Methods and Findings: In the present study, blood samples were obtained from a subgroup of 16 patients originating from the randomized double-blind, placebo-controlled OmegAD study, where 174 Alzheimer disease (AD) patients received daily either 1.7 g of DHA and 0.6 g EPA or placebo for 6 months.
In blood samples obtained from 11 patients receiving n-3 FA and five placebo, expressions of approximately 8,000 genes were assessed by gene array.
Significant changes were confirmed by real-time PCR.
At 6 months, the n-3 FAs group displayed significant rises of DHA and EPA plasma concentrations, as well as up- and down-regulation of 9 and 10 genes, respectively, was noticed.
• Many of these genes are involved in inflammation regulation and neurodegeneration, e.g. CD63, MAN2A1, CASP4, LOC399491, NAIP, and SORL1
• And in ubiqutination processes, e.g. ANAPC5 and UBE2V1. [Ubiqutination processes degrade targeted proteins. “Alteration of the ubiquitination pathway” is thought to play a role in the build-up of plaques in brains of Alzheimer’s and other neurodegenerative illnesses such as Parkinson’s. ]
• Down-regulations of ANAPC5 and RHOB correlated to increases of plasma DHA and EPA levels.
Conclusions: We suggest that 6 months of dietary n-3 FA supplementation affected expression of genes that might influence inflammatory processes and could be of significance for AD.
Trial Registration: ClinicalTrials.gov NCT00211159
Source: PLoS ONE, Apr 24, 2012. By Vedin I, Cederholm T, Freund-Levi Y, Basun H, Garlind A, Irving GF, Eriksdotter-Jonhagen M, Wahlund LO, Dahlman I, Palmblad J. Department of Medicine, and Department of Neurobiology, Caring Sciences and Society, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm; Department of Public Health and Caring Sciences, Division of Geriatrics, and Division of Clinical Nutrition and Metabolism, Uppsala University Hospital, Uppsala, Sweden. Authors have declared that no competing interests exist. [Email: firstname.lastname@example.org]
10 Celebrities With Fibromyalgia [more]
Top 12 Gluten Myths That Are Dangerous to the Fibromyalgia Community [more]
One Year Later - Karina Hansen Still Confined in Mental Ward [more]
VIDEO: How Fibromyalgia Is Often Under-Treated [more]
Study Finds Vitamin D3 Helps with Pain in Fibromyalgia [more]
What’s Up In 2014? A Look Ahead For Chronic Fatigue Syndrome [more]
Why is the CDC Trying to Block an Accurate Lyme Disease Test? [more]
VIDEO: National Press Club Conference on MECFS [more]
Acupoint Stimulation for Fibromyalgia [more]
Live Longer: Groundbreaking Research on Omega-3s [more]