ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|
 
Print Page
Email Article

The Neuroprotective Role of Omega-3 Fatty Acids & Potential Significance for Alzheimer's

  [ 5 votes ]   [ Post a Comment ]
www.ProHealth.com • May 16, 2012

previous article next article

Article:
Effects of DHA-Rich Omega-3 Fatty Acid Supplementation on Gene Expression in Blood Mononuclear Leukocytes: The OmegAD Study
- Source: PLoS ONE, Apr 24, 2012

By Inger vedin, et al.

[Note: to review the full text of this open-access article free, click HERE and scroll down.]

Abstract:
Background: Dietary fish oil, rich in omega-3 fatty acids (n-3 FAs) - e.g. docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) - regulate inflammatory reactions by various mechanisms, e.g. gene activation.

However, the effects of long-term treatment with DHA and EPA in humans, using genome wide techniques, are poorly described.

Hence, our aim was to determine the effects of 6 months of dietary supplementation with an n-3 FA preparation rich in DHA on global gene expression in peripheral blood mononuclear cells.

Methods and Findings: In the present study, blood samples were obtained from a subgroup of 16 patients originating from the randomized double-blind, placebo-controlled OmegAD study, where 174 Alzheimer disease (AD) patients received daily either 1.7 g of DHA and 0.6 g EPA or placebo for 6 months.

In blood samples obtained from 11 patients receiving n-3 FA and five placebo, expressions of approximately 8,000 genes were assessed by gene array.

Significant changes were confirmed by real-time PCR.

At 6 months, the n-3 FAs group displayed significant rises of DHA and EPA plasma concentrations, as well as up- and down-regulation of 9 and 10 genes, respectively, was noticed.

• Many of these genes are involved in inflammation regulation and neurodegeneration, e.g. CD63, MAN2A1, CASP4, LOC399491, NAIP, and SORL1

• And in ubiqutination processes, e.g. ANAPC5 and UBE2V1. [Ubiqutination processes degrade targeted proteins. “Alteration of the ubiquitination pathway” is thought to play a role in the build-up of plaques in brains of Alzheimer’s and other neurodegenerative illnesses such as Parkinson’s. ]

• Down-regulations of ANAPC5 and RHOB correlated to increases of plasma DHA and EPA levels.

Conclusions: We suggest that 6 months of dietary n-3 FA supplementation affected expression of genes that might influence inflammatory processes and could be of significance for AD.

Trial Registration:
ClinicalTrials.gov NCT00211159

Source: PLoS ONE, Apr 24, 2012. By Vedin I, Cederholm T, Freund-Levi Y, Basun H, Garlind A, Irving GF, Eriksdotter-Jonhagen M, Wahlund LO, Dahlman I, Palmblad J. Department of Medicine, and Department of Neurobiology, Caring Sciences and Society, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm; Department of Public Health and Caring Sciences, Division of Geriatrics, and Division of Clinical Nutrition and Metabolism, Uppsala University Hospital, Uppsala, Sweden. Authors have declared that no competing interests exist. [Email: inger.vedin@ki.se]



previous article
  Rating 5 (5 votes) next article




DISCUSS THIS ARTICLE   (0 existing comments) Post a Comment 




[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Omega 3-6-9 Omega 3-6-9
All three EFAs in one convenient form
Vitamin D3 5000 IU Vitamin D3 5000 IU
Give your body a boost with the sunshine vitamin

Most Viewed Articles
What's the Hidden Cause Behind YOUR Fibromyalgia Flares? [more]

Pridgen Reports Fibromyalgia Antiviral Trial Results “Very Positive”: Predicts New Approach Will Be ... [more]

Massage Therapy Studies for Fibromyalgia Reviewed [more]

How to Limit or Minimize Your Fibromyalgia Flare [more]

Mitochondrial Dysfunction, Post-Exertional Malaise and CFS/ME [more]

The Devil Is In The Details – A Herpes Simplex Virus Inquiry For Fibromyalgia and Chronic Fatigue Sy... [more]

Sympathetic Nervous System Dysfunction in FIbromyalgia and Overlapping Conditions [more]

VIDEO: IACFS/ME Conference - Summary of Research by Dr. Komaroff [more]

Review of Nutritional Supplements Used for ME/CFS and FM [more]

FREE: Stop Feeding Yourself PAIN Guide [more]


FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing