Activate Now
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Brain White Matter Abnormalities in Female Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Netwo...

How One LLND Treats Lyme disease and Co-infections Using Natural Medicine

Top 7 Nutrient-Dense Foods That Make Calorie Counting Obsolete

Acupuncture reduces hot flashes in breast cancer survivors

For veterans with Gulf War Illness, an explanation for the unexplainable symptoms

SURVEY: Has Your Illness Affected What You Eat?

DePaul Study Recruiting Participants

Cocoa flavanols lower blood pressure and increase blood vessel function in healthy people

Detection of Invasive Borrelia burgdorferi Strains in North-Eastern Piedmont, Italy.

Mediterranean Diet Plus Olive Oil Associated with Reduced Breast Cancer Risk

Print Page
Email Article

Curcumin could ultimately support drug therapies to defeat devastating viruses, virologists predict

  [ 72 votes ]   [ Discuss This Article ] • August 17, 2012

“Broad-spectrum inhibitors work by defeating a wide array of viruses”…and…“curcumin is, by its very nature, broad spectrum.”

Curcumin, a bioactive component of the popular spice turmeric, “shows promise in fighting devastating viruses,” researchers at George Mason University’s Biodefense & Infectious Diseases Center demonstrated recently.

The study on which they base this statement - published Aug 10 by the Journal of Biological Chemistry - reports that curcumin can stop multiplication of the potentially deadly Rift Valley Fever virus in infected human cells, and has demonstrated antiviral efficacy in infected mice.

Mosquito-borne Rift Valley Fever virus (RVF) is an acute, fever-causing virus that affects domestic animals such as cattle, sheep and goats, as well as humans. Known for stimulating an exaggerated inflammatory response in some patients, this virus has invaded most of Africa and may be considered ‘emerging’, as cases have been identified outside Africa as well.

“In the published article [“Curcumin Inhibits Rift Valley Fever Virus Replication in Human Cells”], we provide evidence that curcumin may interfere with how the virus manipulates the human cell to stop the cell from responding to the infection,” says lead investigator Aarthi Narayanan, PhD.

Importantly, Dr. Narayanan says:

• She intends to apply the research to other viruses, because ‘broad-spectrum inhibitors’ work by defeating a wide array of viruses, and “curcumin is, by its very nature, broad spectrum.”

• In particular she’s interested in a family of viruses that includes Rift Valley Fever virus, called Bunyaviruses, and such alphaviruses as Venezuelan equine encephalitis and retroviruses, which notably include HIV.

• She also plans to test 10 different versions of curcumin to determine which one works the best.

Dr. Narayanan, who has spent the past 18 months working on the RVF project, says she has long wanted to explore the infection-fighting properties of turmeric, and curcumin in particular. “Growing up in India, I was given turmeric all the time,” she explains. “I know this works. I know it works because I have seen it happen in real life….Every time my son has a throat infection, I give (turmeric) to him.”

“It is often not taken seriously because it’s a spice,” she observes, and though science is now transforming that spice from folk medicine to a respected natural agent for immune support, there’s more work to do before curcumin-based pharmaceuticals become commonplace.

Dr. Narayanan and her colleagues study the connection between a virus and how it impacts the host - human or animal. Symptoms clue in the researcher about the body’s inner workings. Rift Valley Fever and Venezuelan Equine Encephalitis kick off with flu-like symptoms, for example. And their symptoms can make it challenging for someone to recover.

The body usually starts with an exaggerated inflammatory response because it doesn’t know where to start to rid itself of the virus, Dr. Narayanan says. “Many times, the body goes above and beyond what is necessary, and that’s not good because it’s going to influence a bunch of cells around the infection, which haven’t seen the bug.”

“That’s one way by which disease spreads through your body. And so it is very important to control the host because a lot of times the way the host responds contributes to the disease.”

Controlling the symptoms means more than simply making the patients feel better.

• “You’re giving the antiviral a chance to work. Now an antiviral can go in and stop the bug.

• “You’re no longer trying to keep the host alive and battling the bug at the same time.”

Once Dr. Narayanan knows how the body responds to a virus, it’s time to go after the bug itself. She delves into uncovering why and how each virus affects the patient.

“Why are some cell types more susceptible to one type of infection than another?”

• HIV goes after the immune system.

• Bunyaviruses will infect a wide range of cells but do maximum damage to the liver. “What is it about the liver that makes it a sitting duck compared to something like the brain?” Dr. Narayanan asks.

Ultimately, curcumin could be part of drug therapies that help defeat these viruses, she concludes.

(Other George Mason University researchers involved in the study are Kylene Kehn-Hall, Charles Bailey, Ravi Das, Irene Guendel, Lindsay Hall, Fatah Kashanchi, Svetlana Senina and Rachel Van Duyne. Also contributing were researchers from George Washington University, the US Army Medical Research Institute of Infectious Disease, Albert Einstein College of Medicine, and the University of Pittsburg Regional Biocontainment Laboratory.)


Source: Based on George Mason University news release, Aug 15, 2012, by Michele McDonald.

Please Discuss This Article:   Post a Comment 

[ Be the first to comment on this article ]

Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

Vitamins and Supplements

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?

What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
M.E. & CFS
Lyme Disease
General Health
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing