ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Social Anxiety Disorder Linked to High Serotonin Levels, Throwing Treatment with SSRIs into Serious ...

A short-term Borrelia burgdorferi infection model identifies tissue tropisms and bloodstream surviva...

Can Botanicals Beat Brain Fog & Fibrofog?

Therapeutic Effects and Mechanisms of Action of Rifaximin in Gastrointestinal Diseases

New Research Substantiates the Anti-Aging Properties of DHEA

Immune response to a flu vaccine yields new insights into narcolepsy

Children with Lyme Disease

Omega-3 supplements and antioxidants may help with preclinical Alzheimer's disease

Promoting Optimal Nutrition with Digestive Enzymes

7-Keto DHEA The Fat-Burning Metabolite of DHEA

 
Print Page
Email Article

Cytotoxic lymphocyte microRNAs as prospective biomarkers for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

  [ 1 vote ]   [ Discuss This Article ]
By Ekua W Benu, Sonya M Marshall-Gradisnik, et al. • www.ProHealth.com • October 9, 2012


[Note: microRNAs (miRNAs) are biological regulators of cell function [see video]. Aberrant expression of microRNAs has been implicated in numerous disease states, with the result that investigations to identify, understand and potentially manipulate them represent a cutting-edge field of research.]

Background: Immune dysfunction associated with a disease often has a molecular basis.

A novel group of molecules known as microRNAs (miRNAs) have been associated with suppression of translational processes involved in cellular development and proliferation, protein secretion, apoptosis, immune function and inflammatory processes.

MicroRNAs may be implicated in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), where immune function is impaired.

The objective of this study was to determine the association between miRNAs in cytotoxic cells and CFS/ME. ['Cytotoxic' denotes 'cell-killing'.]

Methods:

Natural Killer (NK) and CD8(+)T cells were preferentially isolated from peripheral blood mononuclear cells from all participants (CFS/ME, n = 28; mean age = 41.8 +/- 9.6 years; and controls, n = 28; mean age = 45.3 +/- 11.7 years), via negative cell enrichment.

Following total RNA extraction and subsequent synthesis of cDNA, reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) was used to determine the expression levels of nineteen miRNAs.

Results:

• There was a significant reduction in the expression levels of miR-21, in both the NK and CD8(+)T cells in the CFS/ME sufferers.

• Additionally, the expression of miR-17-5p, miR-10a, miR-103, miR-152, miR-146a, miR-106, miR-223 and miR-191 was significantly decreased in NK cells of CFS/ME patients in comparison to the non-fatigued controls.

Limitations: The results from these investigations are not yet transferable into the clinical setting, further validatory studies are now required.

Conclusions:

• Collectively these miRNAs have been associated with apoptosis, cell cycle, development and immune function.

• Changes in miRNAs in cytotoxic cells may reduce the functional capacity of these cells and disrupt effective cytotoxic activity along with other immune functions in CFS/ME patients.

Source: Journal of Affective Disorders, May 7, 2012 [fee-based article]. PMID:22572093, by Brenu EW, Ashton KJ, van Driel M, Staines DR, Peterson D, Atkinson GM, Marshall-Gradisnik SM. Faculty of Health Science and Medicine, Population Health and Neuroimmunology Unit, Bond University, Robina, Queensland, Australia. [Email: ekbrenu@bond.edu.au]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Cocoa's Polyphenol Riches – All the Health Benefits without the Sugar, Calories and Guilt Cocoa's Polyphenol Riches – All the Health Benefits without the Sugar, Calories and Guilt
SAD? Coping with Seasonal Affective Disorder
Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold
Complete and Natural Menopause Relief Complete and Natural Menopause Relief
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing