ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Ultrasound Therapy for Fibromyalgia and Lyme Disease

Curcumin: The All In One Solution, Part 2

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Why You Should Take Your Apple Cider Vinegar at Night

Use Burdock Oil to Promote Healthy Hair Growth

AMA journal associates iron deficiency with hearing loss

Meet Your Weight Loss Goals

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

Lutein linked to preservation of crystallized intelligence

 
Print Page
Email Article

Are ME/CFS and fibromyalgia tryptophan-associated disorders?

  [ 13 votes ]   [ 1 Comment ]
www.ProHealth.com • October 6, 2012


Article:
A Brief Historic Overview of Clinical Disorders Associated with Tryptophan: The Relevance to Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM)
- Source: International Journal of Tryptophan Research, Sep 17, 2012

By Adele Blankfield, BSc

[Note: The full text PDF of this article is available free HERE. It reviews research suggesting that up-regulation of the ‘kynurenine pathway’ may play a role in the clusters of signs and symptoms that predominate in ME/CFS and fibromyalgia patients.

What is the kynurenine pathway? It’s complex, but we located this brief video by biochemist Wesley Hurrell which diagrams the pathway; how its chronic up-regulation may lead to tryptophan and serotonin depletion & produce chronic Th1-immune activation; and the association with symptoms common in ME/CFS and fibromyalgia, including IBS, cognitive impairment, sleep disturbances and depression.]

Abstract:
Last century there was a short burst of interest in the tryptophan-related disorders of pellagra and related abnormalities that are usually presented in infancy.1,2 [L-Tryptophan is an essential amino acid that is a precursor to many neurotransmitters and neurochemicals, including serotonin and melotonin.]

Nutritional physiologists recognized that a severe human dietary deficiency of either tryptophan or the B group vitamins could result in central nervous system (CNS) sequelae such as ataxia [lack of muscle coordination], cognitive dysfunction and dysphoria [anxiety/restlessness], accompanied by skin hyperpigmentation.3,4

The current paper will focus on the emerging role of tryptophan in chronic fatigue syndrome (CFS) and fibromyalgia (FM).

Source: International Journal of Tryptophan Research, Sep 17, 2012; 5, 27-32. DOI: 10.4137/IJTR.S10085, by Blankfield A. Kew, Australia. [Email: gjshnier@bigpond.net.au]





Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra EPA  - Fish Oil Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

Problems with tryptophan beyond kynurenine
Posted by: RolfHefti
Oct 7, 2012
The many problems related to kynurenine are just one of the problematic issues with tryptophan.

This research paper seems to insinuate that tryptophan itself isn't a problem (inferred from observed effects of an endogenous tryptophan deficiency), but primarily the chronic release of kynurenines. However, serotonin, for which tryptophan is its precursor, has been shown to be involved in numerous disease conditions, from brain degeneration, cancer, cardiovascular events, and many others (see http://www.supplements-and-health.com/tryptophan-side-effects.html). This doesn't indicate that the loading of tryptophan or serotonin, with drugs or dietary supplements, is biologically desired.
Reply Reply
 
NAD+ Ignite with Niagen

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Help for Soreness and Swelling: What Do Silkworms Have to Do With It? Help for Soreness and Swelling: What Do Silkworms Have to Do With It?
Coconut Oil - Healthy Gifts from the 'Tree of Life' Coconut Oil - Healthy Gifts from the 'Tree of Life'
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map