ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Study bodes well for low-carb eaters

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Omega Fix for Obesity: How the Right Fats Fight Fat

Potential of Quercetin in the Treatment of Melanoma

How Pomegranate May Protect Against Cancer

Trimming the spare tire: Canola oil may cut belly fat

 
Print Page
Email Article

Strong new evidence that MS risk affected by birth month, mom's vitamin D status

  [ 9 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 20, 2012


Article:
The month of birth effect in multiple sclerosis: Systematic review, meta-analysis and effect of latitude
- Source: Journal of Neurology, Neurosurgery & Psychiatry, Nov 14, 2012. 

By Ruth Dobson, et al.

[Note: The free full text PDF of this article is available here. It reports on a first-time analysis of several large populations living at latitudes in the Northern Hemisphere where UV light is insufficient to produce vitamin D in an expectant mother's skin between October and March. Significantly greater risk of MS was found in people born at those latitudes during April and May (after the winter months) than for those born during October and November (after the summer months).]

Background: Month of birth has previously been described as a risk factor for multiple sclerosis (MS). This has been hypothesized to be related to maternal vitamin D levels during pregnancy, although conclusive evidence to support this is lacking.

To date, no large studies of latitudinal variation in the month of birth effect have been performed to advance this hypothesis.

Methods: Previously published data on month of birth from 151,978 MS patients were compared to expected birth rates. A linear regression model was used to assess the relationship between latitude and observed: expected birth ratio of MS patients for each month.

Results: Analysis of all reported data demonstrated a significant excess of MS risk in those born in April (observed-to-expected 1.05, p=0.05) and reduction in risk in those born in October (0.95, p=0.04) and November (0.92 p=0.01).

A conservative analysis of 78,488 patients revealed an excess MS risk in those born in April (1.07, p=0.002) and May (1.11, p=0.0006), and a reduced risk in those born in October (ratio 0.94, p=0.004) and November (0.88, p=0.0002). [A risk ratio of 1.0 would indicate no difference in risk; thus the risk ratio of 1.11 for May would indicate risk above expected of 11%, and the 0.88 ratio for November would indicate 12% less risk than expected for November births.]

A significant relationship between latitude and observed-to-expected ratio was demonstrated in December, and borderline significant relationships in May and August.

Conclusions: Month of birth has a significant effect on subsequent MS risk. This is likely to be due to ultraviolet light exposure and maternal vitamin D levels, as demonstrated by the relationship between risk and latitude.

Source: Journal of Neurology, Neurosurgery & Psychiatry, Nov 14, 2012. Dobson R, Giovannoni G, Ramagopalan S. Queen Mary University of London, Blizard Institute, Barts and the London School of Medicine and Dentistry, London; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford; Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK. [Email: ruth.dobson@qmul.ac.uk]





Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Vitamin D3 Extreme™ Ultra ATP+, Double Strength


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
Enhance Eyelashes Naturally Enhance Eyelashes Naturally
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map