ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimm...

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Acupressure reduced fatigue in breast cancer survivors

Omega-3 fatty acid stops known trigger of lupus

What’s Fenugreek Good For?

Print Page
Email Article

Creatine Supplementation Improved Muscle Function in Fibromyalgia

  [ 2 votes ]   [ 4 Comments ] • April 8, 2013

Editor's Note: Creatine is a nitrogen-containing organic acid produced in the body from amino acids.  It supports muscle function by working as a reserve energy supply in muscle cells and helping to maintain adenosine triphosphate (ATP) levels.  Muscular contractions are powered by the breakdown of ATP to ADP (adenosine diphosphate). When all the ATP is broken down, creatine phosphate in a muscle donates a phosphate group to ADP and rebuilds ATP, thus promoting further energy reactions.


Creatine supplementation in fibromyalgia: A double-blind, randomized, placebo-controlled trial.
– Source: Arthritis Care & Research, April 1, 2013

By Christiano R. R. Alves, et al.


OBJECTIVE: To investigate the efficacy and safety of creatine supplementation in fibromyalgia patients.

METHODS: A 16-week, double-blind, randomized, parallel-group, placebo-controlled trial was conducted. Fibromyalgia patients were randomly assigned to receive either creatine monohydrate or placebo in a double-blind fashion. The patients were evaluated at baseline and after 16 weeks. Muscle function, aerobic conditioning, cognitive function, quality of sleep, quality of life, kidney function, and adverse events were assessed. Muscle phosphorylcreatine content was measured through phosphorus magnetic resonance spectroscopy.

RESULTS: After the intervention,

  • the creatine group presented higher muscle phosphorylcreatine content when compared with the placebo group (+80.3% vs. -2.7%, respectively; p = 0.04).

  • Furthermore, the creatine group presented greater muscle strength than the placebo group in the leg-press and chest-press exercises (creatine: +9.8% and +1.2% vs. placebo: -0.5% and -7.2%, respectively; p = 0.02 and p = 0.002).

  • Isometric strength was greater in the creatine group than in the placebo group (+6.4% and -3.2%, respectively, p = 0.007).

  • However, no general changes were observed in aerobic conditioning, pain, cognitive function, quality of sleep, and quality of life.

  • Food intake remained unaltered and no side effects were reported.

CONCLUSION: Creatine supplementation increased intramuscular phosphorylcreatine content and improved lower- and upper-body muscle function, with minor changes in other fibromyalgia features. These findings introduce creatine supplementation as a useful dietary intervention to improve muscle function in fibromyalgia patients.

Arthritis Care & Research, April 1, 2013. By Christiano R. R. Alves, Bianca M. Santiago, Fernanda R. Lima, Maria C. G. Otaduy, Ana Luisa Calich, Aline C. C. Tritto, Ana Lúcia de Sá Pinto, Hamilton Roschel, Cláudia C. Leite, Fabiana B. Benatti, Eloisa Bonfa and Bruno Gualano. University of Sao Paulo, School of Physical Education and Sports, Rua Professor Mello Moraes, 65 - Sao Paulo - SP - Brazil.

Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Optimized Curcumin Longvida® Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments Post a Comment

Posted by: roge
Apr 8, 2013
so no change in pain , sleep quality and quality of life so what use is their in creatine supplementation then - another useless study
Reply Reply

Posted by: neoplus1
Apr 8, 2013
No mention about fatigue either.


Posted by: roge
Apr 8, 2013
ok yes some increased strength but that is not the main issue of those with fm - our strength for the most is ok, it is the PAIN that we get after using our muscles and tendons and again the study said pain was not changed so again this study really has little to no beneft


Posted by: Kelly Latta
Apr 9, 2013
Patients need to check with their physician before adding this supplement.

Because many patients take far too many NSAIDS in an effort to control their pain they may be at risk for kidney disease. Kidney disease is asymptomatic until it is too late to save the patient and creatine is not recommended for such patients. If you take NSAIDS often make sure a test is done on kidney function before starting this supplement. Patients with diabetes may also be at risk.

As for who it works for it is quite possible there are subgroups of fibromyalgia patients which scientists have yet to find markers for - and like other forms of arthritis the same treatments do not work for every kind of arthritis. As well, not all creatine supplements are of equal quality and some may not have the amount of ingredient claimed. If one brand doesn't work for you, you may wish to try another before concluding that the supplement does not work for a you.
Reply Reply
Natural Pain Relief Supplements

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Prepare Yourself for Cold & Flu Season Prepare Yourself for Cold & Flu Season
Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire
Clinically Studied Joint Relief Product for FM & ME/CFS Clinically Studied Joint Relief Product for FM & ME/CFS

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map