ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

CDC Whistleblower Reveals Widespread Manipulation of Scientific Data and Top-Down Pressure on CDC Sc...

Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel

9 Health Benefits of Cucumbers

How Glutathione Can Save Your Life

Preserving Cognitive Function with Aging

Coenzyme Q10 Benefits Symptoms in Gulf War Veterans: Results of a Randomized Double-Blind Study

Antibiotics in early life may alter immunity long-term

New Research Helps Explain Why Elderly Are Prone to Sleep Problems

Brain inflammation dramatically disrupts memory retrieval networks, UCI study finds

VIDEO: Relaxation - Ocean Voyager Part I

 
Print Page
Email Article

Evidence of Brainstem Dysfunction in Fibromyalgia Patients

  [ 8 votes ]   [ 1 Comment ]
www.ProHealth.com • September 27, 2013


Alterations in excitatory and inhibitory brainstem interneuronal circuits in fibromyalgia: Evidence of brainstem dysfunction.

By M. Kofler and W. Halder

Abstract:

OBJECTIVE:
Patients with fibromyalgia syndrome (FMS) perceive stimuli differently and show altered cortical sensory representation maps following peripheral stimulation. Altered sensory gating may play a causal role.

METHODS:
Blink reflex, blink reflex excitability recovery, and prepulse inhibition of the blink reflex - representing brainstem excitability - were assessed in 10 female patients with FMS and 26 female healthy controls.

RESULTS:

  • Unconditioned blink reflex characteristics (R1 latency and amplitude, R2 and R2c latency and area-under-the-curve) did not differ significantly between patients and controls.

  • Blink reflex excitability recovery was enhanced in patients versus controls at all intervals tested.

  • Prepulses significantly suppressed R2 area and increased R2 latency in patients and controls.

  • However, R2 area suppression was significantly less in patients than in controls (patients: to 80.0±28.9%, controls: to 47.8±21.7%).

  • The general pattern of corresponding changes in R2c was similar.

CONCLUSIONS: Blink reflex is normal, whereas blink reflex excitability recovery is enhanced and blink reflex prepulse inhibition is reduced in patients with FMS, suggesting functional changes at the brainstem level in FMS.

SIGNIFICANCE: Reduced blink reflex prepulse inhibition concurs with altered sensory gating in patients with FMS.

Copyright © 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Source: Clinical Neurophysiology, September 12, 2013. By M. Kofler and W. Halder. Department of Neurology, Hochzirl Hospital, Zirl, Austria.




Please Discuss This Article:   Post a Comment 

Interesting
Posted by: IanH
Sep 27, 2013
I studied reflex and other prepulse inhibition under the influence of cannabinoids. This same phenomenon occurs under the influence of many neurological drugs.
It also occurs in some forms of schizophrenia.

It implies to me that the immune system cyokines, probably Il-6 and TNF-alpha as well as chronically elevated IFN-gamma are behind this lack of excitation inhibition maybe via impaired neuron-mitochondrial function.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamin B-12

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health

Natural Remedies

Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Live Longer: Groundbreaking Research on Omega-3s Live Longer: Groundbreaking Research on Omega-3s
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
VIDEO: Healthy Eating and Fibromyalgia VIDEO: Healthy Eating and Fibromyalgia
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing