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Most clinical studies on vitamins flawed by poor methodology

  [ 9 votes ]   [ 3 Comments ]
www.ProHealth.com • January 5, 2014


Most clinical studies on vitamins flawed by poor methodology

Press Release: Oregon State University, December 30, 2013

CORVALLIS, Ore. – Most large, clinical trials of vitamin supplements, including some that have concluded they are of no value or even harmful, have a flawed methodology that renders them largely useless in determining the real value of these micronutrients, a new analysis suggests.

Many projects have tried to study nutrients that are naturally available in the human diet the same way they would a powerful prescription drug. This leads to conclusions that have little scientific meaning, even less accuracy and often defy a wealth of other evidence, said Balz Frei, professor and director of the Linus Pauling Institute at Oregon State University, in a new review published in the journal Nutrients.

These flawed findings will persist until the approach to studying micronutrients is changed, Frei said. Such changes are needed to provide better, more scientifically valid information to consumers around the world who often have poor diets, do not meet intake recommendations for many vitamins and minerals, and might greatly benefit from something as simple as a daily multivitamin/mineral supplement.

Needed are new methodologies that accurately measure baseline nutrient levels, provide supplements or dietary changes only to subjects who clearly are inadequate or deficient, and then study the resulting changes in their health. Tests must be done with blood plasma or other measurements to verify that the intervention improved the subjects’ micronutrient status along with biomarkers of health. And other approaches are also needed that better reflect the different ways in which nutrients behave in cell cultures, lab animals and the human body.

The new analysis specifically looked at problems with the historic study of vitamin C, but scientists say many of the observations are more broadly relevant to a wide range of vitamins, micro nutrients and studies.

“One of the obvious problems is that most large, clinical studies of vitamins have been done with groups such as doctors and nurses who are educated, informed, able to afford healthy food and routinely have better dietary standards than the public as a whole,” said Frei, an international expert on vitamin C and antioxidants.

Vitamin or mineral supplements, or an improved diet, will primarily benefit people who are inadequate or deficient to begin with, OSU researchers said. But most modern clinical studies do not do baseline analysis to identify nutritional inadequacies and do not assess whether supplements have remedied those inadequacies. As a result, any clinical conclusion made with such methodology is pretty much useless, they said.

“More than 90 percent of U.S. adults don’t get the required amounts of vitamins D and E for basic health,” Frei said. “More than 40 percent don’t get enough vitamin C, and half aren’t getting enough vitamin A, calcium and magnesium. Smokers, the elderly, people who are obese, ill or injured often have elevated needs for vitamins and minerals.

“It’s fine to tell people to eat better, but it’s foolish to suggest that a multivitamin which costs a nickel a day is a bad idea.”

Beyond that, many scientists studying these topics are unaware of ways in which nutrients may behave differently in something like a cell culture or lab animal, compared to the human body. This raises special challenges with vitamin C research in particular.

“In cell culture experiments that are commonly done in a high oxygen environment, vitamin C is unstable and can actually appear harmful,” said Alexander Michels, an LPI research associate and lead author on this report. “And almost every animal in the world, unlike humans, is able to synthesize its own vitamin C and doesn’t need to obtain it in the diet. That makes it difficult to do any lab animal tests with this vitamin that are relevant to humans.”

Even though such studies often significantly understate the value of vitamin supplements, the largest and longest clinical trial of multivitamin/mineral supplements found a total reduction of cancer and cataract incidence in male physicians over the age of 50. It suggested that if every adult in the U.S. took such supplements it could prevent up to 130,000 cases of cancer each year, Frei said.

“The cancer reduction would be in addition to providing good basic health by supporting normal function of the body, metabolism and growth,” he said. “If there’s any drug out there that can do all this, it would be considered unethical to withhold it from the general public. But that’s basically the same as recommending against multivitamin/mineral supplements.”

Journal Reference: Alexander Michels, Balz Frei. Myths, Artifacts, and Fatal Flaws: Identifying Limitations and Opportunities in Vitamin C Research. Nutrients, 2013; 5 (12): 5161 DOI: 10.3390/nu5125161



Please Discuss This Article:   Post a Comment 

Supplement-bashing news is usually politics
Posted by: Fallo
Jan 5, 2014
It seems most of the public doesn't seem to get that healthcare is run by politics and not by sound evidence. The "flaws" of the anti-supplement allegations include many areas. From faulty research methodology, erroneous misleading "studies," distortions against supplements made by various representatives of mainstream medicine, to bias in reporting by the corporate media all of which is heavily rooted in politics. For some real facts on this deceptive rhetoric and these anti-supplement maneuvers google/bing "2 Big Lies: No Vitamin Benefits & Supplements Are Very Dangerous by Rolf Hefti"
Reply Reply

Minimal levels to correct inadequacies do not reflect those for optimum health
Posted by: Photo1776Bill
Jan 22, 2014
"Vitamin or mineral supplements, or an improved diet, will primarily benefit people who are inadequate or deficient to begin with, OSU researchers said. But most modern clinical studies do not do baseline analysis to identify nutritional inadequacies and do not assess whether supplements have remedied those inadequacies."

Not only do most of us not know if we are deficient, but adequate consumption levels use R.D.A.'s, which are set at low levels to prevent conditions such as scurvy or rickets. They do not necessarily reflect levels needed for optimum health. Nor do they address the other factors such as chronic illness or age-related decline in absorption/utilization that may necessitate higher intake. Mineral deficiencies may be more widespread than vitamin. Personally, the greatest boost to my CFS low-energy levels came from supplementing with magnesium citrate. With our increasing exposure to toxins, the effects of antioxidants need more clinical studies. Unfortunately, large-scale studies are expensive and those with the money to spend (the pharmaceutical industry) are not interested unless the product can be patented so we will have to continue to rely on smaller studies and personal/anecdotal evidence.
Reply Reply

Linus Pauling Institute, are you kidding me?
Posted by: robertin75
Jan 22, 2014
For those who don't know who Linus Pauling was he was arguably the world's greatest quack.

Please ProHealth do a research before publishing this kind of quackery
Reply Reply


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