ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

CDC Whistleblower Reveals Widespread Manipulation of Scientific Data and Top-Down Pressure on CDC Sc...

How Glutathione Can Save Your Life

Reversing Neurodegeneration with a New Magnesium Compound

Coenzyme Q10 Benefits Symptoms in Gulf War Veterans: Results of a Randomized Double-Blind Study

Brain inflammation dramatically disrupts memory retrieval networks, UCI study finds

Gut Bacteria, Artificial Sweeteners and Glucose Intolerance

Scientists discover how to 'switch off' autoimmune diseases

Clinical trial demonstrates safety, effectiveness of immunotherapy for AdV, BKV, and herpesviruses i...

New estrogen-based compound suppresses binge-like eating behavior in female mice

Surprising discovery: HIV hides in gut, evading eradication

 
Print Page
Email Article

A tricky balancing act: antibiotics versus the gut microbiota

  [ 3 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 23, 2014


Press Release: American Gastroenterological Association (March 10, 2014) — Antibiotics are valuable, potentially life-saving tools that have significantly reduced human morbidity and mortality. Unfortunately, antibiotics may also have unintended consequences from their off-target effects that may increase the risk of many long-term conditions. Recent epidemiologic studies have detected a possible link between antibiotic use in childhood and weight gain1 — with disruption to the normal gut microbiota considered the most likely cause. 
 
“Infancy is an important time in the development of the human microbiota and these studies provide evidence that early exposure to antibiotics may disrupt the early-life microbiota and lead to changes in growth and metabolic development,” says Dr. Laura Cox. New York University. “In animal studies, we are carefully trying to understand how the intestinal microbiota influences body composition and metabolism and what impact antibiotics might have.”
 
Her talk was one of the topics presented at the Gut Microbiota for Health World Summit in Miami, FL. On March 8 and 9, 2014, internationally leading experts discussed the latest advances in gut microbiota research and its impact on health. 
 
Antibiotics came into widespread use after the Second World War, with substantial public health benefits. Use of antibiotics has increased markedly, with infants and children averaging one course of antibiotics every year. Longstanding concerns over the broadening and sometimes inappropriate use of antibiotics (e.g. self-medication, use in viral infections, empirical use of broad-spectrum agents in cancer patients with neutropenia) have focussed primarily on the development of bacterial resistance, but it seems clear that antibiotics can also affect the bacteria we need in our guts, as well as those we want to eradicate. This, it seems, could have serious long-term consequences to our health.

Microbiota beyond the gut

The intestinal microbiota, composed of trillions of microbial cells, undertakes many vital immune, hormonal and metabolic functions. Disruption to normal colonization — through the over-use of antibiotic therapy — could, it has been suggested, be fuelling the dramatic increase in conditions such as obesity, type 1 diabetes, inflammatory bowel disease, allergies and asthma, which have more than doubled in prevalence in many populations. Evidence is also mounting that microbiota resilience decreases with each subsequent course of antibiotics2 and that, once disrupted, the normal microbiota may never recover completely or it may be replaced by resistant organisms.3,4
 
“We are just beginning to understand the roles that the intestinal microbiota plays in normal growth and development,” says Dr. Cox, “and further studies in both humans and experimental animal models are needed to characterize the potential impact of antibiotics on the microbiota and host physiology.”

Body composition and metabolism

The spotlight has recently fallen on the role of the gut microbiota in normal growth and development, with scientists now concerned that altering the microbial balance in the gut with antibiotics may lead to weight gain. Low doses of antibiotics have been used for decades in the agricultural industry to promote weight gain in farm animals, and researchers have reported similar changes in body fat and tissue composition in laboratory animals given low-dose antibiotics.5 Studies are currently underway using sub-therapeutic antibiotic treatment as a tool to disrupt the microbial ecosystem and alter host body composition with the aim of identifying organisms within the microbiota that could either promote or protect against obesity.
 
“We are working hard to understand the link between antibiotic exposure, gut microbiota and body composition,” explains Dr. Cox. “Ultimately, our aim is to develop microbiota restoration strategies following antibiotic treatment to rebalance the gut microbiota and promote healthy growth and development.”
 
The microbial communities that reside in the human gut and their impact on human health and disease are one of the most exciting new areas of research today. To address the most recent advances in this rapidly developing field, scientists and health-care professionals from all over the world came together at the Gut Microbiota for Health World Summit in Miami, FL, on March 8 and 9, 2014. The meeting was hosted by the Gut Microbiota & Health Section of the European Society of Neurogastroenterology and Motility (ESNM) and the American Gastroenterological Association (AGA) Institute, with the support of Danone.

References
 

(1) Trasande L, Blustein J, Liu M, Corwin E, Cox LM, Blaser MJ. Infant antibiotic exposures and early-life body mass. Int J Obes (Lond). 2013 Jan;37(1):16-23. 

(2) Dethlefsen L, Relman DA. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4554-61. 

(3) Ghosh TS, Gupta SS, Nair GB, Mande SS. In silico analysis of antibiotic resistance genes in the gut microflora of individuals from diverse geographies and age-groups. PLoS One. 2013 Dec 31;8(12):e83823.

(4) Sjölund M, Wreiber K, Andersson DI, Blaser MJ, Engstrand L. Long-term persistence of resistant Enterococcus species after antibiotics to eradicate Helicobacter pylori. Ann Intern Med. 2003 Sep 16;139(6):483-7. 

(5) Cho I, Yamanishi S, Cox L, Methé BA, Zavadil J, Li K, et al.. Antibiotics in early life alter the murine colonic microbiome and adiposity. Nature. 2012 Aug 30;488(7413):621-6.
 


Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing