ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

The Significance of Selenium

Print Page
Email Article

Seizures Linked to Autoimmune Disease

  [ 13 votes ]   [ Discuss This Article ] • April 2, 2014

Seizures Linked to Autoimmune Disease
BOSTON, March 31, 2014 /PRNewswire-USNewswire/ -- Patients with an autoimmune disease have a 3.8-fold increased risk of developing epilepsy, according to a new population-level study from Boston Children's Hospital based on health insurance claim data. The study, published online March 31, 2014 in JAMA Neurology, is the largest to date to look at the association between autoimmune disease and epilepsy without a recognized neurological cause.

Epilepsy affects approximately 470,000 children and 2.3 million adults in the U.S. alone. While medical and surgical treatments can be effective in managing the disease, the results are mixed. A growing number of reports, based on small clinical or animal model studies, have begun to link specific autoimmune diseases to cases of epilepsy of previously unknown cause. Epilepsy therapy is largely directed at the symptoms of disease and in about two-thirds of patients, the specific underlying cause of the condition is never found.

"Autoimmunity is strongly linked to seizures. We may be overlooking a treatable mechanism in epilepsy patients," said the study's lead author Kenneth Mandl, MD, MPH, runs Boston Children's Informatics Program (CHIP)'s Intelligent Health Laboratory. "We need to change how we think about clinical management of these conditions."

Mandl and Mei-Sing Ong, PhD, first author of the study, looked at the autoimmunity-epilepsy connection at a population-level by analyzing de-identified claims data related to epilepsy and 12 autoimmune diseases from more than 2.5 million subscribers of a nationwide health insurance carrier.

The researchers found that there was a 3.8-fold increase in the risk of epilepsy for patients with an autoimmune disease and 17.5 percent of epilepsy patients also had an autoimmune disease. The increase in risk of epilepsy varied by form of autoimmunity, ranging from 1.9-fold for psoriasis to 9.4-fold for antiphospholipid syndrome. In addition, the increase in risk was greater among children (5.2-fold) than adults (4.3-fold).

Findings also revealed that autoimmunity patients on select immunosuppressing medications had a lower risk of developing epilepsy.

"These findings suggest a new approach to treating seizures, one based on quieting the immune system," Mandl said.
According to Mandl and Mark Gorman, MD, a Boston Children's neurologist involved with the study, the risk association between epilepsy and autoimmunity suggests that both rheumatologists and neurologists should consider screening their patients for signs of the associated condition.

"There are subtle signs of epilepsy that may suggest to an immunologist that a patient should be assessed by a neurologist," said Gorman. "Similarly, if you are a neurologist, a referral to an immunologist may be warranted if a patient shows subtle signs of autoimmunity."

The team's data did not allow them to explore possible mechanisms behind the association, but they hope to work with collaborators to look for biological links.

"There are many ways in which autoimmunity can affect the brain and cause seizures," said Gorman. "The next step is to find out what they are."
The study was supported by the National Institute for General Medical Sciences (grant number R01GM104303), the National Center for Biomedical Computing (grant number U54LM008748), the Conte Center for Computational System Genomics of Neuropsychiatric Phenotypes (National Institute of Mental Health grant number P50MH94267) and the Australian National Health and Medical Research Council.

Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear
Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire
SAD? Coping with Seasonal Affective Disorder SAD? Coping with Seasonal Affective Disorder
Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
Safely Burn Away Body Fat Safely Burn Away Body Fat

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map