ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fighting Heartburn and Gerd Naturally – And Safely!

Natural Bladder Control, Go Less and Live More

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Trimming the spare tire: Canola oil may cut belly fat

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

The Onion: Cancer Fighter and Food Preserver

Probiotics improve cognition in Alzheimer's patients

Curcumin Reverses the Cellular Damage of Chronic Stress

 
Print Page
Email Article

Abnormal Epidermal Nerve Fiber Density in Fibromyalgia

  [ 7 votes ]   [ Discuss This Article ]
www.ProHealth.com • April 14, 2014


Evidence of abnormal epidermal nerve fiber density in fibromyalgia: Clinical and immunologic implications.

By Xavier J. Caro and Earl F. Winter

Abstract:

Objective: A subset of fibromyalgia (FM) patients exhibits a large fiber, demyelinating peripheral polyneuropathy, akin to that seen in chronic inflammatory demyelinating polyneuropathy (CIDP). It has been suggested that this demyelinating process is likely to be immune mediated. Since it is known that similar, large fiber neuropathic lesions may be associated with a cutaneous small fiber neuropathy (SFN), we sought to determine the prevalence of SFN, as measured by epidermal nerve fiber density (ENFD), in a series of FM patients and clinically healthy controls.

Methods: Forty-one consecutive FM and 47 control subjects underwent a 3 mm punch skin biopsy at the proximal thigh and distal leg near the ankle for ENFD analysis. FM subjects with clinical evidence of a disorder known to be associated with SFN were excluded. FM subjects also underwent clinical study for stocking distribution hypesthesia by pinwheel and vibratory testing, and serologic investigation of a series of cytokine, CIC, and complement measurements.

Results: All FM subjects had evidence of stocking distribution hypesthesia.
  • The mean ENFD for FM subjects was lower than for controls at both the calf (5.8 ± 2.8 SD vs. 7.4 ± 1.9 SD; P < 0.0002) and thigh (9.3 ± 3.2 SD vs. 11.3 ± 2.0 SD; P < 0.0007).

  • There was an inverse correlation between calf ENFD and age, at the time of skin biopsy, in FM subjects (r = - 0.29; P = 0.03), but not in controls. ANCOVA showed that this relationship could not be explained by aging alone, however.

  • Serologic evaluation showed an inverse correlation between calf ENFD in FM subjects and the T-cell/macrophage activation marker, IL-2R (r = - 0.28; P = 0.04).

  • Correlation analysis of thigh ENFD and serum IL-2R did not reach significance (P = 0.08).

  • Analysis of calf/thigh ENFD ratios suggests that ENFD decline in FM is affected by both a diffuse, and a length dependent, process

Conclusion: Calf and thigh ENFD in FM are significantly diminished compared to controls. Advancing age, alone, can not explain this finding. Calf ENFD correlated, though weakly, in an inverse fashion with serum IL-2R (P = 0.04). These findings suggest that SFN is likely to contribute to FM pain complaints; that pain in this disorder arises, in part, from a peripheral immune mediated process; and that measurement of ENFD may be a useful clinical tool in FM.

Copyright © 2014 American College of Rheumatology.

Source: Arthritis & Rheumatology, April 9, 2014. By Xavier J. Caro and Earl F. Winter. Northridge Hospital Medical Center, Professional Building, 18350 Roscoe Boulevard, Suite 418, Northridge, CA, 91325.




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Energy NADH™ 12.5mg FibroSleep™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
Help for Soreness and Swelling: What Do Silkworms Have to Do With It? Help for Soreness and Swelling: What Do Silkworms Have to Do With It?
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map