Activate Now
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

For veterans with Gulf War Illness, an explanation for the unexplainable symptoms

Acupuncture reduces hot flashes in breast cancer survivors

SURVEY: Has Your Illness Affected What You Eat?

Recent Research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: Effe...

DePaul Study Recruiting Participants

Cocoa flavanols lower blood pressure and increase blood vessel function in healthy people

Mediterranean Diet Plus Olive Oil Associated with Reduced Breast Cancer Risk

Chemical exposure linked to rising diabetes, obesity risk

Researchers find 'dormant' parasite cysts are actually quite active

Evidence for abnormal cytokine expression in Gulf War Illness: A preliminary analysis of daily immun...

Print Page
Email Article

The Glutathione System: A New Drug Target in Neuroimmune Disorders

  [ 16 votes ]   [ 3 Comments ]
By G. Morris et al. • • April 29, 2014

By G. Morris et al.


Glutathione (GSH) has a crucial role in cellular signaling and antioxidant defenses either by reacting directly with reactive oxygen or nitrogen species or by acting as an essential cofactor for GSH S-transferases and glutathione peroxidases.

GSH acting in concert with its dependent enzymes, known as the glutathione system, is responsible for the detoxification of reactive oxygen and nitrogen species (ROS/RNS) and electrophiles produced by xenobiotics. Adequate levels of GSH are essential for the optimal functioning of the immune system in general and T cell activation and differentiation in particular. GSH is a ubiquitous regulator of the cell cycle per se. GSH also has crucial functions in the brain as an antioxidant, neuromodulator, neurotransmitter, and enabler of neuron survival.

Depletion of GSH leads to exacerbation of damage by oxidative and nitrosative stress; hypernitrosylation; increased levels of proinflammatory mediators and inflammatory potential; dysfunctions of intracellular signaling networks, e.g., p53, nuclear factor-?B, and Janus kinases; decreased cell proliferation and DNA synthesis; inactivation of complex I of the electron transport chain; activation of cytochrome c and the apoptotic machinery; blockade of the methionine cycle; and compromised epigenetic regulation of gene expression.

As such, GSH depletion has marked consequences for the homeostatic control of the immune system, oxidative and nitrosative stress (O&NS) pathways, regulation of energy production, and mitochondrial survival as well. GSH depletion and concomitant increase in O&NS and mitochondrial dysfunctions play a role in the pathophysiology of diverse neuroimmune disorders, including depression, myalgic encephalomyelitis/chronic fatigue syndrome and Parkinson's disease, suggesting that depleted GSH is an integral part of these diseases.

Therapeutical interventions that aim to increase GSH concentrations in vivo include N-acetyl cysteine; Nrf-2 activation via hyperbaric oxygen therapy; dimethyl fumarate; phytochemicals, including curcumin, resveratrol, and cinnamon; and folate supplementation.

Source: Morris G, Anderson G, Dean O, Berk M, Galecki P, Martin-Subero M, Maes M. Mol Neurobiol. 2014 Apr 22. [Epub ahead of print]

Please Discuss This Article:   Post a Comment 

add to this
Posted by: IanH
Apr 29, 2014
The sublingual GSH does work. In fact you can take any powdered version of GSH under the tongue for about 1 minute and blood levels rise significantly.
Reply Reply

another great way to boost glutathione: liposomes
Posted by: richcarson
Apr 30, 2014
Liposomal glutathione is also very effective in raising levels of the glutathione enzymes in the body, and in fact, ProHealth sells just such a product.
Reply Reply

Acetyl Glutathione
Posted by: GlutathionePRO
Apr 30, 2014
You can orally supplement GSH levels with the bioavailable form, Acetyl Glutathione.
Regular glutathione supplements have also been proven to increase levels when taken in high doses long term. However much of the supplement goes to waste due to damage caused in the digestive tract. For the best results use an Acetyl glutathione supplement paired with GSH precursors like N Acetylcysteine, R-alpha lipoic acid and Silymarin.
Reply Reply

Post a Comment

Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

Vitamins and Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed
"It's Not Easy Being Green" - But It Is Healthy

What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
M.E. & CFS
Lyme Disease
General Health
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing