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Co-Q10 Could Have Significant Inflammatory Lowering Effects

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By L. Fan, et al. • www.ProHealth.com • May 16, 2017


Editor’s Note: Co-Q10 is sometimes also recommended by Lyme-literate doctors such as Joseph Burrascano, MD for supporting the heart and aiding in energy production in chronic Lyme disease.
 
Effects of coenzyme Q10 supplementation on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials
 
Abstract
 
The aims of this meta-analysis were to evaluate the effects of coenzyme Q10 (CoQ10) supplementation on inflammatory mediators including C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-? (TNF-?) by analyzing published randomized controlled trials (RCTs).
 
A systematic search in PubMed, Cochrane Library and Clinicaltrials.gov was performed to identify eligible RCTs. Data synthesis was performed using a random- or a fixed-effects model depending on the results of heterogeneity tests, and pooled data were displayed as weighed mean difference (WMD) and 95% confidence interval (CI).
 
Seventeen RCTs were selected for the meta-analysis. CoQ10 supplementation significantly reduced the levels of circulating CRP (WMD: -0.35mg/L, 95% CI: -0.64 to -0.05, P=0.022), IL-6 (WMD: -1.61pg/mL, 95% CI: -2.64 to -0.58, P=0.002) and TNF-? (WMD: -0.49pg/mL, 95% CI: -0.93 to -0.06, P=0.027).
 
The results of meta-regression showed that the changes of CRP were independent of baseline CRP, treatment duration, dosage, and patients characteristics. In the meta-regression analyses, a higher baseline IL-6 level was significantly associated with greater effects of CoQ10 on IL-6 levels (P for interaction=0.006).
 
In conclusion, this meta-analysis of RCTs suggests significant lowering effects of CoQ10 on CRP, IL-6 and TNF-?. However, results should be interpreted with caution because of the evidence of heterogeneity and limited number of studies.
 
Source: By Fan L1, Feng Y2, Chen GC3, Qin LQ4, Fu CL5, Chen LH6. Effects of coenzyme Q10 supplementation on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2017 May;119:128-136. doi: 10.1016/j.phrs.2017.01.032. Epub 2017 Feb 5.
 




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