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Evaluation of succinylcholine-induced fasciculations & myalgias with or without atracurium pretreatment

  [ 46 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 14, 1996


Pretreatment regimens that decrease the incidence of fasciculations
and postoperative myalgias have been the focus of many
research studies. The subject of pretreatment remains
controversial. An experimental double blind study was
conducted of 50 patients, men and women, aged 18 to 65 years
who were having elective minor orthopedic surgery. Group A
participants (n = 24) received normal saline, and group B
participants (n = 26) received atracurium 0.05 mg/kg, followed
by succinylcholine 1.5 mg/kg. Data that were collected
included age, ASA physical status, weight, height, anesthesia
and postanesthesia recovery times, type of procedure,
medications administered, and allergies. Phase I of the study
consisted of evaluation for the presence of fasciculations. In
phase II, the intubation conditions (e.g., character of the
vocal cords, presence of coughing, and degree of ease with
laryngoscopy) were evaluated. Phase III included evaluation of
postoperative myalgias at 24 and 72 hours. Data were analyzed
using measures of central tendency, chi square, Pearson's r
and the Student's t test. The incidence of fasciculations was
less in the atracurium pretreatment group (group B) than in
the group treated with normal saline (group A). Intubation
conditions were not compromised by atracurium pretreatment.
There was no statistically significant difference between
group B and group A in postoperative myalgias. Thus, no
recommendations for pretreatment can be made on the basis of
this study.

Hochhalter CM





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