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The Treatment of Fibromyalgia with Alpha-Stim Cranial Electrotherapy Stimulation

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www.ProHealth.com • October 15, 2001




Lichtbroun, Alan S., Raicer, Mei-Ming C., and Smith, Ray B. The Treatment of Fibromyalgia with Cranial Electrotherapy Stimulation, Journal of Clinical Rheumatology, 7(2):72-78, 2001.

Summary

This study found that Alpha-Stim CES is as effective as the drug therapies, with no negative side effects, and deserves further consideration as an additional agent for the treatment of fibromyalgia.

Methods

After successful clinical use of Alpha-Stim CES (cranial electrotherapy stimulation) in the first author’s rheumatology practice, and IRB approval from Robert Wood Johnson Medical School, a double-blind, placebo-controlled study was undertaken in which 60 randomly assigned patients who completed informed consent were given either 3 weeks of subsensation (100 microamperes) CES treatment at 0.5 Hz for one hour daily (N=20), sham treatment (N=20), or served as controls for any placebo effect in the sham treated patients (N=20). All patients met the diagnostic criteria set forth by the American College of Rheumatology. The age range was from 23 to 82 years (mean of 50). There were 2 men and 58 women suffering from fibromyalgia from 1 to 40 years, (mean of 11 years).

The subjects were randomly assigned into three separate groups by an office secretary who drew their names, which were on separate, sealed slips of paper in a container. Groups I and II were assigned to CES devices that would provide either subsensation treatment or sham treatment (no electric current). Group III served as wait-in-line placebo controls (no treatment), to control for any placebo effect experienced by the sham treated group.

The Alpha-Stim SCS was used. Each device was preset to provide a set amount of current, and it automatically turned off at the end of an hour. The current could not be increased. All treatment was given via electrodes clipped to the earlobes.

Sham treatment was provided by identical ear clip electrodes that did not pass current. All ear clip electrodes had a number etched on them, identifying each as real or sham treating, and the code was kept in a sealed envelope away from the study site.

Results

Treated patients showed a significant improvement in tender point scores (p<.01), and a significant improvement in self-rated scores of general pain level (p<.002). The number of subjects rating their quality of sleep as poor dropped from 60% at the beginning of the study to 5% (p<.02). In addition, there were significant gains in the self-rated feeling of well-being (p<.05), and quality-of-life (p<.03), plus fairly dramatic gains in six stress related psychological test measures of the Profile of Mood States. No placebo effect was found among the sham treated patients.

Second Open Study

After the double-blind study, 23 of the 40 control patients opted for actual CES in an open clinical trial where they could increase the current in accordance with the standard clinical protocols for Alpha-Stim CES. They also showed a significant improvement in tender point scores (p<.001), and in self-rated pain (p<.005), quality of sleep (p<.001), feeling of well-being (p<.001), and quality-of-life (p<.001). Overall there was a 27% reduction in self-rated pain, and a 28% decrease in the tender point scores of the treated group.

Further Conclusions

According to a review of 34 studies of drug treatment for fibromyalgia, adverse effects from drugs are seen in 20% of fibromyalgia patients who use them, and improvement from prescription drugs was reported as 28% at best. In addition, unlike with the use of medication, there is no ongoing cost to the patient after purchase of the CES device. Accordingly, the authors concluded that Alpha-Stim CES is as effective as the drug therapies, with no negative side effects, and deserves further consideration as an additional agent for the treatment of fibromyalgia.

Keywords: Alpha Stim, Cranial Electrotherapy Stimulation, Stress, Fibromyalgia.



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