October 10, 2000
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You may already know something about SAM-E from the news, magazine articles, medical journals, books, the Internet, physicians or friends. The reason behind much of the attention being paid to SAM-E is the significant amount of scientific evidence supporting its use. There are over 75 clinical studies on SAM-E worldwide, involving thousands of people, that appear in scientific publications. One respected medical journal published a very positive collection of studies on SAM-E totaling over 100 pages.
There are many sources of credible information on SAM-E. It is important, though, that you refer to this information when taking Nature Made SAM-E.
What is SAM-e?
SAM-E (S-adenosylmethionine) was first discovered in 1952 and has been commercially available in Europe since the 1970's. SAM-E is an important compound that occurs in every living cell and takes part in several biological reactions in the human body. The important physiological results of these reactions are the manufacture of joint cartilage and the maintenance of neural cell membrane function.
SAM-E has been studied extensively and has been clinically found to support and promote
-- Joint Health, Mobility and Joint Comfort*
-- Mood and Emotional Well-being*
Because SAM-E is involved in so many important body processes, supplementation with SAM-E promises to deliver far reaching benefits. Some clinical studies, for example, conclude that SAM-E supports and promotes liver health.*
Now that SAM-E is available in the U.S., scientists and physicians here are likely to devote significant attention to SAM-E and to further study all the benefits that SAM-E appears to deliver.
Sources of SAM-e
Although SAM-E is present in all living organisms, significant amounts of the substance are not readily available through foods. Nature Made's SAM-E is the result of a sophisticated and patented process developed and owned by one of Nature Made's global pharmaceutical partners. The process involves the cultivation of a special SAM-E producing yeast, the subsequent collection of SAM-E from the yeast, and the integration of SAM-E into a stable compound. The resulting compound is then put into a specially formulated and enteric coated tablet to further enhance stability, provide release of SAM-E in the intestinal tract where it is best absorbed, and increase ease of swallowing. This stable and bio-available form of SAM-E is now available in the U.S.
One of the advantages of SAM-E over other compounds is its remarkable safety profile. In clinical studies, orally administered SAM-E was typically compared against other compounds or placebo for benefits. SAM-E was well tolerated and generally demonstrated an incidence of side effects lower than other compounds and similar to and sometimes lower than placebo.
Many of the clinical studies conducted on SAM-E are published in medical journals. The full text of these studies can be obtained by contacting the appropriate journals. Abstracts of some studies can be found on the Internet. Several popular books cite many clinical studies as references. As SAM-E gains popularity in the U.S., we anticipate that new studies and scientific information will become available.
For optimal absorption into the body, the best time to take SAM-E is 2 hours before or 3 hours after a meal.
To support and promote joint health, mobility and joint comfort, take 1 tablet twice a day. Clinical studies indicate that benefits may be evident in the first two weeks of supplementation and may continue for a prolonged period of time. To determine the proper level of supplementation that works best for you, gradually increase the number of tablets, up to 8 tablets a day, until benefits are achieved.
For optimal mood and emotional well-being, take 1 tablet in the morning and 1 tablet in the afternoon. Taking SAM-E at bedtime may interfere with a good night's rest. Clinical studies indicate that benefits may be evident within one week of supplementation. If benefits are not achieved in two weeks, you may require a higher level of supplementation. To determine the proper level of supplementation that works best for you, gradually increase the number of tablets, up to 8 tablets a day, until benefits are achieved.
SAM-E can be used regardless of the number of benefits that are being sought.
If you are taking antidepressant medications, consult your physician before using this product. Individuals with bipolar (manic) depression should not use this product unless under medical supervision.
SAM-e and Physicians
Since SAM-E is new to the U.S. and because it is a dietary supplement and not a drug, many U.S. physicians are not aware of SAM-E. Nature Made is involved in many programs to help educate U.S. physicians. If your physician is not aware of SAM-E, he or she may not be able to comment on SAM-E. If this happens, suggest that he or she read this package insert or direct your physician to contact Nature Made for scientific information.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Source: This information was provided by Nature Made.