Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Patient Insights into the Design of Technology to Support a Strengths-Based Approach to Health Care.

SURVEY: Weight Management & Chronic Illness

Japanese green tea consumers have reduced risk of dementia

Do Nothing, Accomplish Everything! The Connection Between Breathing and Healing

Meet the ProHealth Editors

Best Herbs to Help With Insomnia

Choline: Why You Should Eat Your Egg Yolks and Take Krill

Calcium, vitamin D supplementation associated improved stroke recovery

Acupressure reduced fatigue in breast cancer survivors

More positive evidence for melatonin in breast cancer battle

 
Print Page
Email Article

Genes May Enhance Ill Health From Organophosphate Exposure

  [ 14 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 7, 2002




By Harvey McConnell (02/28/2002)

Source: The Lancet


Some farmers appear to have a genetic predisposition to the adverse health effects associated with exposure to organophosphate in sheep dip.

Results of a study by Dr Nicola Cherry and colleagues from the University of Manchester "provide support for those who believe that repeated exposure to organophosphates may cause chronic ill health."

Exposure to organophosphates has acute effects on health, but evidence of chronic effects is unclear. Many people who have been occupationally exposed to these chemicals, especially in sheep farming, think them to be a cause of poor health.

Clinicians explain that human serum paraoxonase (PON1) hydrolyses organophosphates. Isoforms of the enzyme, which differ in their PON1 activity, result from aminoacid substitutions at positions 192 (glutamine to arginine) and 55 (leucine to methionine). The effect of the 192 polymorphism depends upon the substrate; diazinonoxon, the active metabolite of diazinon, an organophosphate often used in sheep dip chemicals in the UK, is hydrolysed more slowly by the R than the Q alloenzyme.

Dr Cherry investigated the relation between genetic variations in the gene regulating paraoxonase and health outcomes in farmers. The researchers recruited 175 farmers who reported ill health attributed to exposure to sheep dip. In turn, the farmers nominated 234 other farmers who also dipped sheep and whom they believed to be in good health.

Researchers calculated the odds ratios for polymorphisms in the gene regulating paraoxonase, and therefore the ability to break down toxic organophosphates. Farmers who reported poor health were nearly twice as likely than the healthy farmers to have specific alterations in the gene regulating paraoxonase.

These farmers were more likely to have at least one R allele at position 192 (glutamine to arginine aminoacid substitution; odds ratio 1.93, 95 percent CI 1.24-3.01), both alleles of type LL (1.70, 1.07-2.68) at position 55, and to have diazoxonase activity below normal median (1.77, 1.18"2.67).

"Our results support the hypothesis that organophosphates contribute to the reported ill health of people who dip sheep, " the researchers said.

Dr Cherry in comments, said: "The study was set up to test a clear hypothesis, that those whose genes produced a less efficient enzyme would, if exposed to organophosphates, be more likely to become ill.

"The results provide support for those who believe that repeated exposure to organophosphates may cause chronic ill health. Sheep dippers in the UK are one important group, but there are many others world-wide who are exposed to these chemicals and whose health may be affected as a result."


Lancet 2002; 359: 763-64.



Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil FibroSleep™ Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Magnesium: An Essential Supplement for ME/CFS Magnesium: An Essential Supplement for ME/CFS
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map