Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Patient Insights into the Design of Technology to Support a Strengths-Based Approach to Health Care.

Greater intake of dietary omega-3 fatty acids associated with lower risk of diabetic retinopathy

SURVEY: Weight Management & Chronic Illness

Japanese green tea consumers have reduced risk of dementia

Researchers find herpes strain in the nervous system

Do Nothing, Accomplish Everything! The Connection Between Breathing and Healing

Nature Heals

Best Herbs to Help With Insomnia

Meet the ProHealth Editors

Choline: Why You Should Eat Your Egg Yolks and Take Krill

 
Print Page
Email Article

Chronic Infections Impair Immune Response - Chronic Fatigue Syndrome & Fibromyalgia News

  [ 317 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 29, 2003


Chronic infections and excessive immune responses cause reduced T-cell antigen æ expression  By Tudor Toma

The T-cell antigen receptor zeta (æ) chain contains signal-transducing motifs, and its downregulation has been linked with impaired in vitro T-cell function in cancer and autoimmune and infectious diseases. However, the exact molecular mechanisms involved are unknown. In the September 21 Nature Immunology, Noemí Bronstein-Sitton and colleagues at the Hebrew University-Hadassah Medical School show that reduced æ expression is the normal outcome of an excessive and potentially hazardous immune response (Nature Immunology, DOI:10.1038/ni975, September 21, 2003).

Bronstein-Sitton et al. used an in vivo system that mimics chronic infections by exposing healthy mice to heat-killed Porphyromonas gingivalis. They observed that sustained exposure of mice to bacterial antigens was sufficient to induce T-cell antigen receptor æ chain downregulation and impair T-cell function. In addition, the authors showed that downregulation of æ correlated with an impaired in vivo T-cell–mediated immune response—a phenomenon that required interferon ãand a TH1-dependent immune response.

"We propose that æd own-regulation could be one of the mechanisms that 'shuts off' an inappropriately extreme immune response, thus maintaining balance in the immune system," conclude the authors.

Links for this article:

E.W. Shores P.E. Love, "TCR zeta chain in T cell development and selection," Current Opinion in Immunology, 9:380-389, June 1997.
[PubMed Abstract]

N. Bronstein-Sitton et al., "Sustained exposure to bacterial antigen induces interferon-ã -dependent T cell receptor æ down-regulation and impaired T cell function," Nature Immunology, DOI:10.1038/ni975, September 21, 2003. http://www.nature.com/ni/

Hebrew University-Hadassah Medical School http://www.md.huji.ac.il/

Source: The-Scientist.com



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt
Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask
Clinically Studied Joint Relief Product for FM & ME/CFS Clinically Studied Joint Relief Product for FM & ME/CFS
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Complete and Natural Menopause Relief Complete and Natural Menopause Relief

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map