Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Big step towards cure for HIV and other lifelong viral infections

SURVEY RESULTS: Attitudes About Fatigue

Superfood Trio: Ginger, Turmeric, and Carrots?

How Omega-3 Fights Depression

Rejuvenate Your Skin Naturally With Sea Buckthorn Oil

A Smile

Can Drinking More Water Help You Lose Weight?

Resveratrol’s Link to Slowing Alzheimer’s

Tropical Turmeric Carrot Juice & Smoothie

Most Everyone Can Use More Vitamin D

 
Print Page
Email Article

Chronic Infections Impair Immune Response - Chronic Fatigue Syndrome & Fibromyalgia News

  [ 317 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 29, 2003


Chronic infections and excessive immune responses cause reduced T-cell antigen æ expression  By Tudor Toma

The T-cell antigen receptor zeta (æ) chain contains signal-transducing motifs, and its downregulation has been linked with impaired in vitro T-cell function in cancer and autoimmune and infectious diseases. However, the exact molecular mechanisms involved are unknown. In the September 21 Nature Immunology, Noemí Bronstein-Sitton and colleagues at the Hebrew University-Hadassah Medical School show that reduced æ expression is the normal outcome of an excessive and potentially hazardous immune response (Nature Immunology, DOI:10.1038/ni975, September 21, 2003).

Bronstein-Sitton et al. used an in vivo system that mimics chronic infections by exposing healthy mice to heat-killed Porphyromonas gingivalis. They observed that sustained exposure of mice to bacterial antigens was sufficient to induce T-cell antigen receptor æ chain downregulation and impair T-cell function. In addition, the authors showed that downregulation of æ correlated with an impaired in vivo T-cell–mediated immune response—a phenomenon that required interferon ãand a TH1-dependent immune response.

"We propose that æd own-regulation could be one of the mechanisms that 'shuts off' an inappropriately extreme immune response, thus maintaining balance in the immune system," conclude the authors.

Links for this article:

E.W. Shores P.E. Love, "TCR zeta chain in T cell development and selection," Current Opinion in Immunology, 9:380-389, June 1997.
[PubMed Abstract]

N. Bronstein-Sitton et al., "Sustained exposure to bacterial antigen induces interferon-ã -dependent T cell receptor æ down-regulation and impaired T cell function," Nature Immunology, DOI:10.1038/ni975, September 21, 2003. http://www.nature.com/ni/

Hebrew University-Hadassah Medical School http://www.md.huji.ac.il/

Source: The-Scientist.com



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra EPA  - Fish Oil Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
SAD? Coping with Seasonal Affective Disorder SAD? Coping with Seasonal Affective Disorder
Guarding Against the Dangers of Vitamin D Deficiency Guarding Against the Dangers of Vitamin D Deficiency

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map