ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Gut Bacteria, Artificial Sweeteners and Glucose Intolerance

Reverse Mitochondrial Damage

Culprits of Autism Identified: Toxins, Gut Bacteria, Nutritional Deficiencies, and Vaccines Made wit...

Turmeric compound boosts regeneration of brain stem cells

Use of Broad-Spectrum Antibiotics Before Age 2 Associated with Obesity Risk

CoQ10: The Longevity Factor

Is Homocysteine Making You Sick?

VIDEO: Beautiful Clouds - Relaxation and Meditation

Magnesium: Widespread Deficiency with Deadly Consequences

Elevated plasma biomarkers of chronic inflammation in Gulf War illness

 
Print Page
Email Article

Multiple sclerosis breakthrough: Vitamin D directly terminates production of disease-causing protein

  [ 54 votes ]   [ 4 Comments ]
www.ProHealth.com • August 16, 2011


Mechanism suggests a potential new path toward pharmaceutical treatment of MS, as well as therapies for other autoimmune diseases such as rheumatoid arthritis, type 1 diabetes, eczema and psoriasis.

For years scientists have noted an association between levels of vitamin D in a person’s body and the person’s ability to resist or minimize the effects of multiple sclerosis (MS) but didn’t understood the mechanism involved. Until now.

New breakthrough research by a collaborative team at UMDNJ-New Jersey Medical School and Stanford indicates that vitamin D directly terminates the production of a disease-causing protein.

As the investigators outline in their report, published in the September issue of Molecular and Cellular Biology (“1,25-Dihydroxyvitamin D3 ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A”):

• During MS (“EAE” in mice), a damaging protein called interleukin-17 (IL-17) is produced by immune cells in the brain.

• The research team found that after vitamin D binds to its receptor, the receptor parks itself on the gene that encodes IL-17.

• By doing so, the vitamin D receptor occupies a site normally reserved for a protein called NFAT, which is required to turn the IL-17 gene on.

• The gene stays off and IL-17 levels plummet.

• At the same time, the vitamin D receptor turns on another gene, whose product generates suppressive T cells that combat the destructive action of their IL-17-producing counterparts.

According to the researchers, led by UMDNJ Prof. Sylvia Christakos, PhD, the mechanism they identified suggests what might be a new path toward pharmaceutical treatment of MS, as well as therapies for other autoimmune diseases that might include rheumatoid arthritis, type 1 diabetes, eczema and psoriasis.

Source: UMDNJ news release, Aug 16, 2011



Please Discuss This Article:   Post a Comment 

link not working
Posted by: IanH
Aug 17, 2011
This link is not working: (“1,25-Dihydroxyvitamin D3 ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A” ):
Reply Reply

 
Fixed link
Posted by: IanH
Aug 18, 2011
Thanks. The link is now working.

 


Vitamin D connection MS
Posted by: Foxley
Aug 19, 2011
As the article describes a property of Vitamin D, why would they not recommend research on Vitamin D, and use of Vitamin D, rather than needing to develop a new drug before people can benefit?
Reply Reply

disease causing protein
Posted by: nickjones
Sep 29, 2011
This seems like it is great news for those with MS and other autoimmune diseases such as rheumatoid arthritis, type 1 diabetes, eczema and psoriasis. It is fantastic that they have found that vitamin D directly terminates the production of a disease-causing protein. If you know someone who has an autoimmune disease such as type 1 diabetes, it is important to know which physicians have expertise in in the recent vitamin D findings. Is there a physician that can help them determine the appropriate treatment or help them figure out how much vitamin D should be in their diet? Thanks for your help! Best, Nick Jones
Reply Reply


Post a Comment

 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Protecting Our Eyes Against Time-Induced Damage Protecting Our Eyes Against Time-Induced Damage
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing