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MS breakthrough may provide new understanding, new treatments

  [ 22 votes ]   [ Discuss This Article ] • October 6, 2011

The possible role of cranio-cervical trauma and abnormal CSF hydrodynamics in the genesis of Multiple Sclerosis
– Source: Physiological Chemistry and Physics & Medical NMR, Sep 20, 2011

By Raymond V Damadian and David Chu

[Note: To read the full text pdf of the article abstracted below, which discusses observation of a process involved in at least the cases of multiple sclerosis included in this study, go to Interestingly, the observed cerebrospinal fluid flow obstruction was worse in the upright than the prone position.]

UPRIGHT® Multi-Position™ MR scanning has uncovered a key set of new observations regarding Multiple Sclerosis (MS), which observations are likely to provide a new understanding of the origin of MS.

The new findings may also lead to new forms of treatment for MS.

The UPRIGHT® MRI has demonstrated pronounced anatomic pathology of the cervical spine [vertebrae of the neck] in five of the MS patients studied and definitive cervical pathology in the other three. The pathology was the result of prior head and neck trauma.

All eight MS patients entered the study on a first come first serve basis without priority, and all but one were found to have a history of serious prior cervical trauma which resulted in significant cervical pathology. The cervical pathology was visualized by UPRIGHT® MRI.

• Upright cerebrospinal fluid (CSF) cinematography and quantitative measurements of CSF velocity, CSF flow and CSF pressure gradients in the upright patient revealed that significant obstructions to CSF flow were present in all MS patients.

• The obstructions are believed  to be responsible for CSF “leakages” of CSF from the ventricles [structures in the brain containing crebrospinal fluid] into the surrounding brain parenchyma [nerve tissue] which “leakages” can be the source of the MS lesions in the brain that give rise to MS symptomatology. The CSF flow obstructions are believed to result in increases in intracranial pressure (ICP) that generate “leakages” of the CSF into the surrounding brain parenchyma.

• In all but one MS patient, anatomic pathologies were found to be more severe in the upright position than in the recumbent position.

• Similarly, CSF flow abnormalities were found to be more severe in the upright position than in the recumbent position in all but one MS patient.

Images of the MS patient anatomic pathologies and CSF flow abnormalities are provided with comparison images from normal examinees in Figures 1–15.

Physiological Chemistry and Physics & Medical NMR, Sep 20, 2011. Damadian RV, Chu D. FONAR Corporation, Melville, New York, USA. [Email:]

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