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Why All Migraine Patients Should Be Treated with Magnesium - Source: Journal of Neural Transmission, May 2012

  [ 92 votes ]   [ 2 Comments ]
By Alexander Mauskop, Jasmine Varughese • • May 3, 2012

Magnesium, the second most abundant intracellular cation, is essential in many intracellular processes and appears to play an important role in migraine pathogenesis.

Routine blood tests do not reflect true body magnesium stores since less than 2% is in the measurable, extracellular space, 67% is in the bone and 31% is located intracellularly.

Lack of magnesium may promote cortical spreading depression, hyperaggregation of platelets, affect serotonin receptor function, and influence synthesis and release of a variety of neurotransmitters.

Migraine sufferers may develop magnesium deficiency due to:

• Genetic inability to absorb magnesium,

• Inherited renal magnesium wasting,

• Excretion of excessive amounts of magnesium due to stress,

• Low nutritional intake,

• And several other reasons.

There is strong evidence that magnesium deficiency is much more prevalent in migraine sufferers than in healthy controls.

Double-blind, placebo-controlled trials have produced mixed results, most likely because both magnesium deficient and non-deficient patients were included in these trials. This is akin to giving cyanocobalamin in a blinded fashion to a group of people with peripheral neuropathy without regard to their cyanocobalamin levels.

Both oral and intravenous magnesium are:

• Widely available,

• Extremely safe,

• Very inexpensive

• And for patients who are magnesium deficient can be highly effective.

Considering these features of magnesium, the fact that magnesium deficiency may be present in up to half of migraine patients, and that routine blood tests are not indicative of magnesium status - empiric treatment with at least oral magnesium is warranted in all migraine sufferers.

Source: Journal of Neural Transmission, May 2012;119(5), 575-579. DOI: 10.1007/s00702-012-0790-2, by Mauskop A, Varughese J. New York Headache Center, New York; CUNY Brooklyn College, New York, NY, USA. [Email:]

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Article Comments Post a Comment

Fascinating solutions
Posted by: IanH
May 3, 2012
Isn't it great how, with more basic research we find the simpler solutions to many problems. There is a tendency for scientists (like me) to think everything must require a complex explanation and treatment and go looking for complex and expensive drugs. We do need to look more at the nutritional and lifestyle solutions FIRST.
Reply Reply

Thankful for great scientists!
Posted by: FaithHopeCure
May 5, 2012
So thankful for great scientists who are able to publish their findings and share the information with wellness seekers!
Reply Reply
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