The fibromyalgia family study: A genome-scan linkage study.
– Source: Arthritis and Rheumatism, December 28, 2012. [Epub ahead of print]
By Lesley M. Arnold, et al.
Objective: Familial aggregation of fibromyalgia has been increasingly recognized. The goal of the current study was to conduct a genome wide linkage scan to identify susceptibility loci for fibromyalgia.
Methods: We genotyped members of 116 families from the Fibromyalgia Family Study and performed a model-free genome-wide linkage analysis of fibromyalgia with 341 microsatellite markers, using the Haseman-Elston regression approach.
Results: The estimated sibling recurrence risk ratio (?(s) ) for fibromyalgia was 13.6 (95% CI: 10.0-18.5), based on a reported population prevalence of 2%. Genome-wide suggestive evidence of linkage was found at marker D17S2196 (Empirical P =0.00030) and D17S1294 (Empirical P =0.00035) on chromosome 17p11.2-q11.2.
Conclusion: The estimated sibling recurrence risk ratio suggests a strong genetic component of fibromyalgia.
This is the first study to report genome-wide suggestive linkage of fibromyalgia to the chromosome 17p11.2-q11.2 region.
Further investigation of these multi-case families from the Fibromyalgia Family Study is warranted to identify potential causal risk variants for fibromyalgia. © 2012 American College of Rheumatology.
Source: Arthritis and Rheumatism, December 28, 2012. [Epub ahead of print]. By Lesley M. Arnold, I. Jon Russell, Muhammad B. Yunus, M.A. Khan, I. Kushner, J.M. Olson, S.K. Iyengar. Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio. E-mail: Lesley.Arnold@uc.edu.