Editor's Comment: Interstitial cystitis is a common comorbidity among patients with ME/CFS and fibromyalgia. Dr. Jay Goldstein observed that 20% of his patients experienced pain upon urination, while other physicians have placed that percentage even higher (up to 90%). For those who suffer from this condition, constant bladder pain can be just as disabling as any other symptom.
Increased Pro-Inflammatory Cytokines, C-Reactive Protein and Nerve Growth Factor Expressions in Serum of Patients with Interstitial Cystitis/Bladder Pain Syndrome
Yuan-Hong Jiang et al.
Objective: The etiology and pathogenesis of interstitial cystitis/bladder pain syndrome (IC/BPS) are unclear. Chronic inflammation is considered the main pathology of IC/BPS. This study measured the serum c-reactive protein (CRP), nerve growth factor (NGF) and pro-inflammatory cytokine/chemokine interleukin (IL)-1?, IL-6, tumor necrosis factor (TNF)-?, and IL-8 expression in patients with IC/BPS to elucidate the involvement of systemic inflammation in IC/BPS.
Methods: Serum samples were collected from 30 IC/BPS patients and 26 control subjects. The concentrations of serum nerve growth factor (NGF), IL-1?, IL-6, TNF-?, and IL-8 were quantified using a bead-based, human serum adipokine panel kit. Serum C-reactive protein
(CRP) was also assessed. Differences of serum CRP, NGF, IL-1?, IL-6, TNF-?, and IL-8 levels between the IC/BPS patients and controls were compared, and correlations between CRP and pro-inflammatory cytokines and chemokine were also evaluated.
Results: The results showed that CRP level (p = 0.031), NGF (p = 0.015) and pro-inflammatory cytokines/chemokine IL-1?, IL-6, TNF-?, and IL-8 levels were significantly higher in the patients with IC/BPS than among controls (all p<0.001). Significant associations were observed between IL-1? and IL-8 (p<0.001), IL-6 and CRP (p = 0.01), IL-6 and IL-8 (p = 0.02), and IL-6 and TNF-? (p = 0.03).
Conclusion: Increased pro-inflammatory cytokines/chemokine (IL-1?, IL-6, TNF-?, and IL-8) expression in the sera of IC/BPS patients implies not only mast cell activation, but also that other inflammatory mediators play important roles in the pathogenesis of IC/BPS. Thus, for some patients, IC/BPS is considered a chronic inflammatory disease.
Source: PLoS ONE 8(10): e76779 doi:10.1371/journal.pone.0076779.Jiang Y-H, Peng C-H, Liu H-T, Kuo H-C (2013) Increased Pro-Inflammatory Cytokines, C-Reactive Protein and Nerve Growth Factor Expressions in Serum of Patients with Interstitial Cystitis/Bladder Pain Syndrome.