Activate Now
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Brain White Matter Abnormalities in Female Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Netwo...

Top 7 Nutrient-Dense Foods That Make Calorie Counting Obsolete

How One LLND Treats Lyme disease and Co-infections Using Natural Medicine

For veterans with Gulf War Illness, an explanation for the unexplainable symptoms

Acupuncture reduces hot flashes in breast cancer survivors

SURVEY: Has Your Illness Affected What You Eat?

DePaul Study Recruiting Participants

Cocoa flavanols lower blood pressure and increase blood vessel function in healthy people

Detection of Invasive Borrelia burgdorferi Strains in North-Eastern Piedmont, Italy.

Mediterranean Diet Plus Olive Oil Associated with Reduced Breast Cancer Risk

Print Page
Email Article

Hyperexcitable C Nociceptors in Fibromyalgia

  [ 10 votes ]   [ Discuss This Article ]
By Jordi Serra, MD, et al. • • December 9, 2013

Editor's comment:  Nociceptors are nerve cells that respond to potentially damaging stimuli by sending  signals – usually perceived as pain – to the brain and spinal cord.  In this study, researchers found that the function of certain nociceptors is abnormal in most people with fibromyalgia. 


Objective: To test the hypothesis that peripheral C nociceptor function may be abnormal in fibromyalgia and that C nociceptor dysfunction may contribute to the symptoms reported by these patients.

Methods: Microneurography was used to record from C nociceptors of 30 female patients meeting criteria for fibromyalgia and compared with recordings from 17 female patients with small fiber neuropathy and 9 female controls.

Results: We obtained stable recordings from 186 C nociceptors in the fibromyalgia group, 114 from small fiber neuropathy patients, and 66 from controls.

  • The mechano-sensitive nociceptors in the fibromyalgia patients behaved normally, but the silent nociceptors in 76.6% of fibromyalgia patients exhibited abnormalities.

  • Spontaneous activity was detected in 31% of silent nociceptors in fibromyalgia, 34% in small fiber neuropathy, and 2.2% in controls.

  • Sensitization to mechanical stimulation was found in 24.2% of silent nociceptors in fibromyalgia, 22.7% in small fiber neuropathy, and 3.7% in controls.

  • Abnormally high slowing of conduction velocity when first stimulated at 0.25 Hz was more common in fibromyalgia.

Interpretation: We show for the first time that the majority of fibromyalgia patients have abnormal C nociceptors. Many silent nociceptors exhibit hyperexcitability resembling that in small fiber neuropathy, but high activity-dependent slowing of conduction velocity is more common in fibromyalgia patients, and may constitute a distinguishing feature. We infer that abnormal peripheral C nociceptor ongoing activity and increased mechanical sensitivity could contribute to the pain and tenderness suffered by patients with fibromyalgia.

Annals of Neurology, November 16, 2013. By Jordi Serra MD, Antonio Collado MD, Romà Solà MD, Francesca Antonelli MD, Xavier Torres MD, Monika Salgueiro MD, Cristina Quiles MD and Hugh Bostock PhD, FRS. Department of Neurology, MC Mutual, Barcelona, Spain; Neuroscience Technologies, Parc Científic de Barcelona, Barcelona.

Please Discuss This Article:   Post a Comment 

[ Be the first to comment on this article ]

Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

Vitamins and Supplements

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
Health Benefits Are Brewing in Green Tea Health Benefits Are Brewing in Green Tea
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!

What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
M.E. & CFS
Lyme Disease
General Health
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing