ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Omega Fix for Obesity: How the Right Fats Fight Fat

How Pomegranate May Protect Against Cancer

Trimming the spare tire: Canola oil may cut belly fat

The Onion: Cancer Fighter and Food Preserver

Safely Reduce a Common Cause of Stomach Distress

 
Print Page
Email Article

Small Nerve Fiber Involvement in FIbromyalgia Patients

  [ 9 votes ]   [ 1 Comment ]
www.ProHealth.com • February 17, 2014


Small nerve fiber involvement in patients referred for fibromyalgia.

By Maria Pia Giannoccaro MD, et al.

Abstract:

Introduction: Fibromyalgia (FM) is a chronic syndrome characterized by widespread pain often accompanied by other symptoms suggestive of neuropathic pain. We evaluated patients for small fiber neuropathy (SFN) who were referred for fibromyalgia (FM).

Methods: We studied 20 consecutive subjects with primary FM. Patients underwent neurological examination, nerve conduction studies, and skin biopsies from distal leg and thigh.

Results: Electrodiagnostic studies were normal in all patients. SFN was diagnosed in 6 patients by reduced epidermal nerve fiber density. These patients also showed abnormalities of both adrenergic and cholinergic fibers.

Conclusion: A subset of FM subjects have SFN, which may contribute to their sensory and autonomic symptoms. Skin biopsy should be considered in the diagnostic work-up of FM. Muscle Nerve, 2014.

Source: Muscle & Nerve, December 28, 2013. By Maria Pia Giannoccaro MD, Vincenzo Donadio PhD, Alex Incensi BSc, Patrizia Avoni PhD and Rocco Liguori MD. Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.




Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra EPA  - Fish Oil Mitochondria Ignite™ with NT Factor®


Article Comments Post a Comment

We need more info
Posted by: IanH
Feb 19, 2014
We need to know the genetics of the people now to ascertain whether the SFN (small fibre neuropathy) is causing the fibromyalgia syndrome or whether it is a result of a separate pathology in which "fibromyalgia" is a symptom set eg ME/CFS.

There are several explanations as to why about 30% of people with diagnosed FM might have SFN but not all cases.

Genetics:

The genes SCN9A or SCN10A are mutated in about 35% of cases of small fiber neuropathy.

These genes code for the alpha subunits of two different sodium channels, Nav1.7 and Nav1.8.

Sodium channels transport positively charged sodium ions into cells and play a key role in a cell's ability to generate and transmit electrical signals. The NaV1.7 and NaV1.8 sodium channels are found in nociceptors that transmit pain signals to the spinal cord and brain.

The mutations cause "leakages":
The SCN9A gene mutations result in NaV1.7 sodium channels that do not close completely when the channel is turned off.

Some of the SCN10A gene mutations result in NaV1.8 sodium channels that open more easily than usual.

The altered channels allow sodium ions to flow abnormally into nociceptors. This increase in sodium ions enhances transmission of pain signals, causing individuals to be more sensitive to stimulation that might otherwise not cause pain.

In this condition, the small fibers that extend from the nociceptors degenerate over time. The cause of this degeneration is unknown, (but see my notes below). The gradual degeneration likely accounts for signs and symptoms such as the loss of temperature differentiation and pinprick sensation. So we get increased pain signaling and a degeneration of pain-transmitting fibers. This leads to a variable condition with signs and symptoms that can change over time. (This suggests an immunological cause)

Also, other health conditions can cause this disorder:
Diabetes mellitus and impaired glucose tolerance
Fabry disease
immune disorders such as celiac disease or Sjogren syndrome
sarcoidosis
human immunodeficiency virus (HIV) infection.

Immunological destabilization of the protein subunits:
The alpha subunits of the Nav1.7 channel are affected by low energy output of the Na_K_ATPase

NAv1.7 and NAv1.8 are both modulated by the Protein Kinase A and Protein Kinase C. A down regulation of PKa and/or PKc will interfere with NAv1.8 and NAv1.8 causing the above leakages. Other research has shown dysfunction in PKc and PKa pathways in ME/CFS.

So in summary we have:
genetic differences to account for some SFN
Energetics deficits and elevated ROS and NOS which can account for the SFN
Immune/mRNA pathways which can account for the SFN.

All in all these factors can account for the 30% of FM patients who have SFN. So I am suggesting that the SFN is caused by some "known" mainly immunological disruptions in FM.

Reply Reply
 
Natural Pain Relief Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS
Bone Broth Benefits for Digestion, Arthritis and Cellulite Bone Broth Benefits for Digestion, Arthritis and Cellulite
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map