ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Gut Bacteria, Artificial Sweeteners and Glucose Intolerance

Culprits of Autism Identified: Toxins, Gut Bacteria, Nutritional Deficiencies, and Vaccines Made wit...

Vitamin E intake critical during 'the first 1,000 days'

Turmeric compound boosts regeneration of brain stem cells

Lower risk of mortality over thirteen year period in association with higher levels of vitamin D

Use of Broad-Spectrum Antibiotics Before Age 2 Associated with Obesity Risk

VIDEO: Beautiful Clouds - Relaxation and Meditation

Reverse Mitochondrial Damage

The Fast-Acting Solution for Healthy Digestive Function

Elevated plasma biomarkers of chronic inflammation in Gulf War illness

 
Print Page
Email Article

Acetyl-L-Carnitine Effective in Treatment of Depression

  [ 7 votes ]   [ 1 Comment ]
www.ProHealth.com • March 14, 2014


Editor's comment: Depression is often a comorbidity with fibromyalgia. This study is a review of clinical trials evaluating the use of acetyl-l-carnitine in the treatment of depression. It includes a 2007 study that focused on the treatment of depressive symptoms in fibromyalgia patients.

Acetyl L-Carnitine (ALC) is a delivery form for L-carnitine, a vitamin-like nutrient that is responsible for transporting long chain fatty acid "fuel" into the cells' energy producing mitrochondria. ALC is able to travel through the blood-brain barrier and plays a role in formation of the brain chemical acetylcholine - a "neurotransmitter."

A review of current evidence for acetyl-l-carnitine in the treatment of depression.

By S.M. Want, et al.

Abstract:

Despite numerous antidepressants available, many patients with depression do not achieve adequate response rendering needs for novel antidepressants with different mechanism of actions. Acetyl-l-carnitine (ALC) is a potential antidepressant with novel mechanism of action because of its diverse functions related with neuroplasticity. Animal and cellular models suggest that ALC's neuroplasiticity effect, membrane modulation, and neurotransmitter regulation may play an important role in treatment of depression.

  • Four randomized clinical studies (RCT) demonstrated the superior efficacy of ALC over placebo (PBO) in patients with depression.

  • Two RCTs showed its superior efficacy over PBO in dysthymic disorder, and

  • 2 other RCTs showed that it is equally effective as fluoxetine and amisulpride in treatment of dysthymic disorder.

  • ALC was also effective in improving depressive symptoms in patients with fibromyalgia and minimal hepatic encephalopathy.

  • It was also found to be equally tolerable to PBO and better tolerable than fluoxetine and amisulpride.

In conclusion, ALC may be potentially effective and tolerable next treatment option with novel action mechanisms for patients with depression, in particular older population and patients with comorbid medical conditions who are vulnerable to adverse events from antidepressants. However, more clinical trial data with adequately-powered, well-designed and advanced methodology will be mandatory to conclude whether ALC as a monotherapy or augmentation agent may be efficacious and clinically beneficial for depression.

Copyright © 2014 Elsevier Ltd. All rights reserved.

Source: Journal of Psychiatric Research, February 15, 2014. Wang SM, Han C, Lee SJ, Patkar AA, Masand PS, Pae CU.




Please Discuss This Article:   Post a Comment 

Acetyl-L-Carnitine Effective in Treatment of Depression - Antidepressants
Posted by: herenow23
Mar 16, 2014
Aloha,

Naturally there are a lot of supplements that are available here which are very helpful. Supplements are especially helpful when we test levels of what we need and find the best way to stimulate our individual biological needs.

I am looking forward to the incorporation of this type of treatment being taught and practiced by all "practitioners". I hope that additional "accurate and unbiased" research for Acetyl-L-Carnitine Effective in Treatment of Depression is funded (if, it's "the best bang for the buck") and is effective. I hope all avenues are pursued and available to the public, properly researched and funded. I'm certain most of us can use all the help we can get.

Mahalos once again for the updates :)

23
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing