Activate Now
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Brain White Matter Abnormalities in Female Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Netwo...

How One LLND Treats Lyme disease and Co-infections Using Natural Medicine

Lyme Camp- A Unique Event for People with Lyme Disease

International Lyme and Associated Diseases Society Hosts Its Annual Scientific Conference in Ft. Lau...

Acupuncture reduces hot flashes in breast cancer survivors

Top 7 Nutrient-Dense Foods That Make Calorie Counting Obsolete

For veterans with Gulf War Illness, an explanation for the unexplainable symptoms

Magnificent Milk Thistle

DePaul Study Recruiting Participants

SURVEY: Has Your Illness Affected What You Eat?

Print Page
Email Article

Acetyl-L-Carnitine Effective in Treatment of Depression

  [ 9 votes ]   [ 1 Comment ] • March 14, 2014

Editor's comment: Depression is often a comorbidity with fibromyalgia. This study is a review of clinical trials evaluating the use of acetyl-l-carnitine in the treatment of depression. It includes a 2007 study that focused on the treatment of depressive symptoms in fibromyalgia patients.

Acetyl L-Carnitine (ALC) is a delivery form for L-carnitine, a vitamin-like nutrient that is responsible for transporting long chain fatty acid "fuel" into the cells' energy producing mitrochondria. ALC is able to travel through the blood-brain barrier and plays a role in formation of the brain chemical acetylcholine - a "neurotransmitter."

A review of current evidence for acetyl-l-carnitine in the treatment of depression.

By S.M. Wang, et al.


Despite numerous antidepressants available, many patients with depression do not achieve adequate response rendering needs for novel antidepressants with different mechanism of actions. Acetyl-l-carnitine (ALC) is a potential antidepressant with novel mechanism of action because of its diverse functions related with neuroplasticity. Animal and cellular models suggest that ALC's neuroplasiticity effect, membrane modulation, and neurotransmitter regulation may play an important role in treatment of depression.

  • Four randomized clinical studies (RCT) demonstrated the superior efficacy of ALC over placebo (PBO) in patients with depression.

  • Two RCTs showed its superior efficacy over PBO in dysthymic disorder, and

  • 2 other RCTs showed that it is equally effective as fluoxetine and amisulpride in treatment of dysthymic disorder.

  • ALC was also effective in improving depressive symptoms in patients with fibromyalgia and minimal hepatic encephalopathy.

  • It was also found to be equally tolerable to PBO and better tolerable than fluoxetine and amisulpride.

In conclusion, ALC may be potentially effective and tolerable next treatment option with novel action mechanisms for patients with depression, in particular older population and patients with comorbid medical conditions who are vulnerable to adverse events from antidepressants. However, more clinical trial data with adequately-powered, well-designed and advanced methodology will be mandatory to conclude whether ALC as a monotherapy or augmentation agent may be efficacious and clinically beneficial for depression.

Copyright © 2014 Elsevier Ltd. All rights reserved.

Source: Journal of Psychiatric Research, February 15, 2014. Wang SM, Han C, Lee SJ, Patkar AA, Masand PS, Pae CU.

Please Discuss This Article:   Post a Comment 

Acetyl-L-Carnitine Effective in Treatment of Depression - Antidepressants
Posted by: herenow23
Mar 16, 2014

Naturally there are a lot of supplements that are available here which are very helpful. Supplements are especially helpful when we test levels of what we need and find the best way to stimulate our individual biological needs.

I am looking forward to the incorporation of this type of treatment being taught and practiced by all "practitioners". I hope that additional "accurate and unbiased" research for Acetyl-L-Carnitine Effective in Treatment of Depression is funded (if, it's "the best bang for the buck") and is effective. I hope all avenues are pursued and available to the public, properly researched and funded. I'm certain most of us can use all the help we can get.

Mahalos once again for the updates :)

Reply Reply
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

Vitamins and Supplements

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones

What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
M.E. & CFS
Lyme Disease
General Health
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing