Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Acupuncture used in clinical settings reduced symptoms of menopause

Benefits of Coconut Oil Are Undeniable

How Awesome Is Ashwagandha?

SURVEY RESULTS: Should Opioids Be Restricted for Chronic Illness?

CoQ10 supplementation associated with lower pro-inflammatory factors in randomized trial

Clinical trial demonstrates success of low FODMAP diet

Research Demonstrates Superiority of Krill Oil Compared to Fish Oil

Vitamin nicotinamide riboside protects mice from diabetes complications

Vitamin-mineral supplement prevents brain cell loss in recent research

What’s so Remarkable About Rosemary?

 
Print Page
Email Article

Abnormal Epidermal Nerve Fiber Density in Fibromyalgia

  [ 7 votes ]   [ Discuss This Article ]
www.ProHealth.com • April 14, 2014


Evidence of abnormal epidermal nerve fiber density in fibromyalgia: Clinical and immunologic implications.

By Xavier J. Caro and Earl F. Winter

Abstract:

Objective: A subset of fibromyalgia (FM) patients exhibits a large fiber, demyelinating peripheral polyneuropathy, akin to that seen in chronic inflammatory demyelinating polyneuropathy (CIDP). It has been suggested that this demyelinating process is likely to be immune mediated. Since it is known that similar, large fiber neuropathic lesions may be associated with a cutaneous small fiber neuropathy (SFN), we sought to determine the prevalence of SFN, as measured by epidermal nerve fiber density (ENFD), in a series of FM patients and clinically healthy controls.

Methods: Forty-one consecutive FM and 47 control subjects underwent a 3 mm punch skin biopsy at the proximal thigh and distal leg near the ankle for ENFD analysis. FM subjects with clinical evidence of a disorder known to be associated with SFN were excluded. FM subjects also underwent clinical study for stocking distribution hypesthesia by pinwheel and vibratory testing, and serologic investigation of a series of cytokine, CIC, and complement measurements.

Results: All FM subjects had evidence of stocking distribution hypesthesia.
  • The mean ENFD for FM subjects was lower than for controls at both the calf (5.8 ± 2.8 SD vs. 7.4 ± 1.9 SD; P < 0.0002) and thigh (9.3 ± 3.2 SD vs. 11.3 ± 2.0 SD; P < 0.0007).

  • There was an inverse correlation between calf ENFD and age, at the time of skin biopsy, in FM subjects (r = - 0.29; P = 0.03), but not in controls. ANCOVA showed that this relationship could not be explained by aging alone, however.

  • Serologic evaluation showed an inverse correlation between calf ENFD in FM subjects and the T-cell/macrophage activation marker, IL-2R (r = - 0.28; P = 0.04).

  • Correlation analysis of thigh ENFD and serum IL-2R did not reach significance (P = 0.08).

  • Analysis of calf/thigh ENFD ratios suggests that ENFD decline in FM is affected by both a diffuse, and a length dependent, process

Conclusion: Calf and thigh ENFD in FM are significantly diminished compared to controls. Advancing age, alone, can not explain this finding. Calf ENFD correlated, though weakly, in an inverse fashion with serum IL-2R (P = 0.04). These findings suggest that SFN is likely to contribute to FM pain complaints; that pain in this disorder arises, in part, from a peripheral immune mediated process; and that measurement of ENFD may be a useful clinical tool in FM.

Copyright © 2014 American College of Rheumatology.

Source: Arthritis & Rheumatology, April 9, 2014. By Xavier J. Caro and Earl F. Winter. Northridge Hospital Medical Center, Professional Building, 18350 Roscoe Boulevard, Suite 418, Northridge, CA, 91325.




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Vitamin D3 Extreme™ Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
All Natural Deodorants

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep? Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep?
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler

· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map