ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Delayed diagnosis of Lyme disease has devastating effect on patients

Missing Link Found Between Brain, Immune System - Major Disease Implications

National Institutes Of Health Discovers Protective Effects Of Coffee

The dormant blood microbiome in chronic, inflammatory diseases

Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?

Association of lyme disease and schizoaffective disorder, bipolar type: Is it inflammation mediated?

Adapt to Stress Naturally with These Power Herbs

Curcumin Made 65X More Bioavailable - Modern Take on a "Golden" Spice Busts Brain Fog, Joint & Body ...

Researchers’ discovery may explain difficulty in treating Lyme disease

Discovering Coffee's Unique Health Benefits

 
Print Page
Email Article

The Glutathione System: A New Drug Target in Neuroimmune Disorders

  [ 16 votes ]   [ 3 Comments ]
By G. Morris et al. • www.ProHealth.com • April 29, 2014


By G. Morris et al.

Abstract

Glutathione (GSH) has a crucial role in cellular signaling and antioxidant defenses either by reacting directly with reactive oxygen or nitrogen species or by acting as an essential cofactor for GSH S-transferases and glutathione peroxidases.

GSH acting in concert with its dependent enzymes, known as the glutathione system, is responsible for the detoxification of reactive oxygen and nitrogen species (ROS/RNS) and electrophiles produced by xenobiotics. Adequate levels of GSH are essential for the optimal functioning of the immune system in general and T cell activation and differentiation in particular. GSH is a ubiquitous regulator of the cell cycle per se. GSH also has crucial functions in the brain as an antioxidant, neuromodulator, neurotransmitter, and enabler of neuron survival.

Depletion of GSH leads to exacerbation of damage by oxidative and nitrosative stress; hypernitrosylation; increased levels of proinflammatory mediators and inflammatory potential; dysfunctions of intracellular signaling networks, e.g., p53, nuclear factor-?B, and Janus kinases; decreased cell proliferation and DNA synthesis; inactivation of complex I of the electron transport chain; activation of cytochrome c and the apoptotic machinery; blockade of the methionine cycle; and compromised epigenetic regulation of gene expression.

As such, GSH depletion has marked consequences for the homeostatic control of the immune system, oxidative and nitrosative stress (O&NS) pathways, regulation of energy production, and mitochondrial survival as well. GSH depletion and concomitant increase in O&NS and mitochondrial dysfunctions play a role in the pathophysiology of diverse neuroimmune disorders, including depression, myalgic encephalomyelitis/chronic fatigue syndrome and Parkinson's disease, suggesting that depleted GSH is an integral part of these diseases.

Therapeutical interventions that aim to increase GSH concentrations in vivo include N-acetyl cysteine; Nrf-2 activation via hyperbaric oxygen therapy; dimethyl fumarate; phytochemicals, including curcumin, resveratrol, and cinnamon; and folate supplementation.

Source: Morris G, Anderson G, Dean O, Berk M, Galecki P, Martin-Subero M, Maes M. Mol Neurobiol. 2014 Apr 22. [Epub ahead of print]



Please Discuss This Article:   Post a Comment 

add to this
Posted by: IanH
Apr 29, 2014
The sublingual GSH does work. In fact you can take any powdered version of GSH under the tongue for about 1 minute and blood levels rise significantly.
Reply Reply

another great way to boost glutathione: liposomes
Posted by: richcarson
Apr 30, 2014
Liposomal glutathione is also very effective in raising levels of the glutathione enzymes in the body, and in fact, ProHealth sells just such a product. http://ow.ly/wjK3E
Reply Reply

Acetyl Glutathione
Posted by: GlutathionePRO
Apr 30, 2014
You can orally supplement GSH levels with the bioavailable form, Acetyl Glutathione.
Regular glutathione supplements have also been proven to increase levels when taken in high doses long term. However much of the supplement goes to waste due to damage caused in the digestive tract. For the best results use an Acetyl glutathione supplement paired with GSH precursors like N Acetylcysteine, R-alpha lipoic acid and Silymarin.
Reply Reply


Post a Comment

 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
Safely Burn Away Body Fat Safely Burn Away Body Fat
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing