ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Missing protein explains link between obesity, diabetes

Fish oil use associated with brain volume preservation

The Brain Boosting and Fatigue Fighting B-12

Genetic basis for distinct type of autism uncovered

Unsuspected aspect of immune regulation revealed: Role of B cells

IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders

Explaining 'Healthy' Obesity

Sinus Congestion and Sinusitis, Healing Naturally

Omega 3 Fatty Acids Lessen Severity of Osteoarthritis in Mice

In the gut, immunity is a two-way street

 
Print Page
Email Article

Abstract: Clinical Endocannabinoid Deficiency (CECD): Can this Concept Explain Therapeutic Benefits of Cannabis in Migraine, Fibromyalgia, Irritable Bowel Syndrome and other Treatment-Resistant Conditions?

  [ 341 votes ]   [ 3 Comments ]
www.ProHealth.com • May 26, 2004


Neuroendocrinol Lett. 2004 Feb-Apr;25(1/2):31-39. Russo EB. Senior Medical Advisor, GW Pharmaceuticals, 2235 Wylie Avenue, Missoula, MT 59802, USA. erusso@montanadsl.net OBJECTIVES: This study examines the concept of clinical endocannabinoid deficiency (CECD), and the prospect that it could underlie the pathophysiology of migraine, fibromyalgia, irritable bowel syndrome, and other functional conditions alleviated by clinical cannabis. METHODS: Available literature was reviewed, and literature searches pursued via the National Library of Medicine database and other resources. RESULTS: Migraine has numerous relationships to endocannabinoid function. Anandamide (AEA) potentiates 5-HT1A and inhibits 5-HT2A receptors supporting therapeutic efficacy in acute and preventive migraine treatment. Cannabinoids also demonstrate dopamine-blocking and anti-inflammatory effects. AEA is tonically active in the periaqueductal gray matter, a migraine generator. THC modulates glutamatergic neurotransmission via NMDA receptors. Fibromyalgia is now conceived as a central sensitization state with secondary hyperalgesia. Cannabinoids have similarly demonstrated the ability to block spinal, peripheral and gastrointestinal mechanisms that promote pain in headache, fibromyalgia, IBS and related disorders. The past and potential clinical utility of cannabis-based medicines in their treatment is discussed, as are further suggestions for experimental investigation of CECD via CSF examination and neuro-imaging. CONCLUSION: Migraine, fibromyalgia, IBS and related conditions display common clinical, biochemical and pathophysiological patterns that suggest an underlying clinical endocannabinoid deficiency that may be suitably treated with cannabinoid medicines. PMID: 15159679 [PubMed - as supplied by publisher]




Discuss This Article Post a Comment 


YES, I kept telling my doctor cannabis helps in so many ways!
Posted by: firstrala
Dec 13, 2007
I am also bipolar and have been on many LEGAL medications for bipolar, fibromyalgia, IBS and nothing worked or had such drastic side effects, I had to stop. After 3 years and seven months 'clean', I began to treat the anxiety and fibro pain with cannabis. Not only am I able to function much better without as much pain, my IBS symptoms are GONE. I haven't had an ER visit since!! KEEP LEARNING AND RESEARCH ALIVE! Short term memory problems are a side effect I can live with.
Reply Reply

forget what u know about cannabis
Posted by: kikky
Apr 13, 2009
I have used cannabis for appetite stimulation and to help manage stress for years. It would not surprise me that there are many other applications. I am in excellent health and can say the myths surrounding cannabis use are just the result of decades of negative propoganda aimed to secure the cotton industry's future. Short term memory loss is not a permanent side affect.
Reply Reply

Short Term Memory Loss
Posted by: rasmarcus
Mar 14, 2010
The "side effect" of short term memory loss is now being considered to be a preventitive measure for Alzheimer’s. See more.. http://www.msnbc.msn.com/id/15145917/
Reply Reply


Post a Comment

 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Featured Products

FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
2 test library cats 2 test library cats
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
"It's Not Easy Being Green" - But It Is Healthy
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing