ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Missing protein explains link between obesity, diabetes

Fish oil use associated with brain volume preservation

The Brain Boosting and Fatigue Fighting B-12

Genetic basis for distinct type of autism uncovered

Unsuspected aspect of immune regulation revealed: Role of B cells

IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders

Explaining 'Healthy' Obesity

Sinus Congestion and Sinusitis, Healing Naturally

Omega 3 Fatty Acids Lessen Severity of Osteoarthritis in Mice

In the gut, immunity is a two-way street

 
Print Page
Email Article

Cytokine patterns in Fibromyalgia and their correlation with clinical manifestations

  [ 153 votes ]   [ Discuss This Article ]
By L Bazzichi, et al. • www.ProHealth.com • June 6, 2007


Journal: Clinical and Experimental Rheumatology. 2007 Mar-Apr;25(2):225-30.

Authors and affiliation: Bazzichi L, Rossi A, Massimetti G, Giannaccini G, Giuliano T, De Feo F, Ciapparelli A, Dell'osso L, Bombardieri S. Department of Internal Medicine, Division of Rheumatology, University of Pisa, Pisa, Italy.

PMID: 17543146

Objective: To examine the possible role of the soluble factor in Fibromyalgia (FM) by studying the correlation of cytokine levels with the patients' clinical and psychiatric profile. [Cytokines are chemical signals released by many types of cells that accomplish cell-to-cell communication. They are made up of water-soluble proteins/glycoproteins, are particularly important in immune responses, and are involved in a variety of immunological, inflammatory, and infectious diseases.]

Methods: Eighty FM patients underwent clinical and psychiatric evaluations, and plasma levels of cytokines (IL-1, IL-6, IL-8, IL-10, TNF-alpha), aspecific markers of inflammation, rheumatoid factor (RF), anti-extractable nuclear antigen (ENA) antibodies, and anti-nuclear factor (FAN) were measured.

Results: Higher levels of IL-10, IL-8 and TNF-alpha were found in FM patients than in controls. Significant correlations between the biochemical parameters and clinical data were found.

Conclusion: The higher levels of cytokines found in FM patients suggest the presence of an inflammatory response system and highlight a parallel between the clinical symptoms and biochemical data. [Inflammatory response is inflammation responding to cellular injury by bacteria, toxins, trauma, or any other cause.] They support the hypothesis that cytokines may play a role in the clinical features of Fibromyalgia.

In addition, the similar cytokine patterns found in FM patients with different psychiatric profiles suggests that inflammatory response system impairment may play a specific role in the disease.





Discuss This Article Post a Comment 




[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

"It's Not Easy Being Green" - But It Is Healthy
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing