ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Delayed diagnosis of Lyme disease has devastating effect on patients

Missing Link Found Between Brain, Immune System - Major Disease Implications

Association of lyme disease and schizoaffective disorder, bipolar type: Is it inflammation mediated?

Adapt to Stress Naturally with These Power Herbs

Curcumin Made 65X More Bioavailable - Modern Take on a "Golden" Spice Busts Brain Fog, Joint & Body ...

Why So Many Arthritis Sufferers Fail to Find Relief

Discovering Coffee's Unique Health Benefits

Safely Manage Joint Inflammation: Curcumin

Bay Area Lyme Foundation Awards Grant to Harvard Medical School Researchers for Development of an Ac...

Therapeutic program reverses cognitive decline

 
Print Page
Email Article

ME/CFS associated with later life non-Hodgkin lymphoma: Medicare statistics

  [ 26 votes ]   [ 2 Comments ]
www.ProHealth.com • June 1, 2012


Article:
Chronic fatigue syndrome and subsequent risk of cancer among elderly US adults 
– Source: Cancer, May 30, 2012

by Cindy M Chang, Joan L Warren, Eric A Engels

[Note: an OR (odds ratio) of 1.0 would signify no difference in average risk between CFS & non-CFS populations. An OR of 1.88, for example, would indicate an 88% greater average risk for the CFS population. OR of 1.51 would be 51% greater average risk, and so on.]

Abstract:
Summary: Using US linked registry data on 1.2 million cancer cases and 100,000 population-based controls, risk was evaluated for a wide range of cancer types following a diagnosis of chronic fatigue syndrome. A strongly significant elevated risk was found for non-Hodgkin lymphoma associated with chronic fatigue syndrome, and in particular, associations for 2 specified non-Hodgkin lymphoma subtypes (diffuse large B cell lymphoma and marginal zone lymphoma).

Background: The cause of chronic fatigue syndrome (CFS) is unknown but is thought to be associated with immune abnormalities or infection.

Because cancer can arise from similar conditions, associations between CFS and cancer were examined in a population-based case-control study among the US elderly.

Methods: Using linked Surveillance, Epidemiology, and End Results (SEER)-Medicare registry data, approximately 1.2 million cancer cases and 100,000 controls (age range, 66-99 years; 1992-2005) were evaluated.

CFS was identified in the period more than 1 year prior to selection, using linked Medicare claims. Unconditional logistic regression was used to estimate the odds ratios (ORs) comparing the CFS prevalence in cases and controls, adjusting for age, sex, and selection year. All statistical tests were 2-sided.

Results:

• CFS was present in 0.5% of cancer cases overall and 0.5% of controls [1 in 200 people in Medicare database].

• CFS was associated with an increased risk of non-Hodgkin lymphoma (NHL) (OR = 1.29, 95% confidence interval [CI] = 1.16-1.43, P = 1.7 × 10?6th).

• Among non-Hodgkin lymphoma subtypes, CFS was associated with diffuse large B cell lymphoma (OR = 1.34, 95% CI = 1.12-1.61), marginal zone lymphoma (OR = 1.88, 95% CI = 1.38-2.57), and B cell NHL not otherwise specified (OR = 1.51, 95% CI = 1.03-2.23).

CFS associations with non-Hodgkin lymphoma overall and NHL subtypes remained elevated after excluding patients with medical conditions related to CFS or non-Hodgkin lymphoma, such as autoimmune conditions.

CFS was also associated, although not after multiple comparison adjustment, with cancers of the pancreas (OR = 1.25, 95% CI = 1.07-1.47), kidney (OR = 1.27, 95% CI = 1.07-1.49), breast (OR = 0.85, 95% CI = 0.74-0.98), and oral cavity and pharynx (OR = 0.70, 95% CI = 0.49-1.00).

Conclusions: Chronic immune activation or an infection associated with CFS may play a role in explaining the increased risk of non-Hodgkin lymphoma.

Source: Cancer, May 30, 2012. DOI: 10.1002/cncr.27612, by Chang CM, Warren JL, Engels EA. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland; Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, Maryland, USA. [Email: Eric A. Engels MD, MPH (engelse@exchange.nih.gov)] National Cancer Institute Senior Investigator Eric Engels, MD, MPH, specializes in study of immunosuppression, infection and inflammation in cancer; Cindy Chang, PhD, MPH, specializes in non-Hodgkin lymphoma research; and Joan L Warren, PhD, specializes in Medicare data analysis for cancer-related research.

The authors note: This study used the linked Surveillance, Epidemiology, and End Results (SEER)-Medicare database. The interpretation and reporting of these data are the sole responsibility of the authors. The authors acknowledge the efforts of the Applied Research Program, National Cancer Institute; the Office of Research, Development, and Information, Centers for Medicare and Medicaid Services; Information Management Services, Inc.; and the SEER Program tumor registries in the creation of the SEER-Medicare database. We thank Winnie Ricker (Information Management Services, Rockville, MD) for assistance with database management.




Please Discuss This Article:   Post a Comment 

Correlation strength
Posted by: blacksnake
Jun 4, 2012

Thank you for posting this article.

I suggest that the OR demonstrates "mild" or "moderate" association between CFS and NHL.

"Strong" is like smoking and lung cancer - OR of 11.
Reply Reply

What about younger patients?
Posted by: aryiella
Jun 23, 2012
This only looked at the correlation for ages 66-99. How can we know if the same increased risk applies to younger ages groups as well? I'm 37 and wondering how much I really need to worry about this right now.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Safely Burn Away Body Fat Safely Burn Away Body Fat
World Famous Joint Relief Formula Enhanced by Modern Science World Famous Joint Relief Formula Enhanced by Modern Science
Coconut Oil - Healthy Gifts from the 'Tree of Life' Coconut Oil - Healthy Gifts from the 'Tree of Life'
When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing