ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Vitamin D Deficiency Linked to Neurological Diseases; Also Raises Risk of Asthma Attacks, and More

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

7 Best Foods You Can Eat

Study: Doubling saturated fat in the diet does not increase saturated fat in blood

The Gut Microbiome and the Brain

Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed

CoQ10 supplementation reduces statin-related muscle pain in randomized trial

Controlling obesity with potato extract

Plant used in traditional Chinese medicine may treat metabolic diseases and obesity

Natural Gut Viruses Join Bacterial “Cousins” in Maintaining Health and Fighting Infections

 
Print Page
Email Article

IV Immunoglobulin May Offer Significant Relief for Neuropathic Pain

  [ 14 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 14, 2012


Article:
Efficacy and Safety of Intravenous Immunoglobulin as Adjuvant Treatment for Refractory Neuropathic Pain. Results of an Open-Label, Multicenter Study
- Source: Pain Medicine, Oct 2012

By Stefano Jann, MD, et al.

[Note: Immunoglobulin, derived from human blood plasma and produced by immune B-cells, is typically used to treat those with immune deficiencies or autoimmune diseases, with generally at most mild side effects. Neuropathy is pain associated with damaged tissue or nerves, or poor microcirculation, and occurs with many disorders.(1) Research by pain expert Roland Staud has suggested many ME/CFS and fibromyalgia patients may have ‘small fiber neuropathy.’]

Abstract:
Introduction: Neuropathic pain is frequently associated with many peripheral nervous system diseases and its successful treatment is an area of significant and critical unmet need.

Methods: Twenty adult outpatients of both sexes who had been suffering from painful polyneuropathy resistant to conventional therapies for at least 6 months and up to a maximum of 5 years and who reported severity of pain greater than 60 units on a visual analog scale (VAS) at baseline were included in this open-label pilot study.

Patients were randomly 1:1 allocated to receive adjuvant intravenous immunoglobulin (IVIg) (Flebogamma®, 2 g/kg) in addition to their regular therapy or to continue with the previous therapy (control group).  [Note: The regular/previous therapies that were not knocking the patients’ pain down enough included pregabalin, oxcarbazepine, duloxetine, and/or oxycodone.]

Results: The mean value of pain intensity (VAS) in the IVIG group:

• Dropped from 88 at baseline to 49 after the first week, and to 28 after 4 weeks, [bolding added]

• While values in the control group only slightly changed, from 85 to 78 after 1 week and to 75 after 4 weeks (P < 0.01).

Almost 100% of patients reported strong/medium pain (Short Form McGill Pain Questionnaire) in both groups at baseline:

• While after 4 to 8 weeks, pain was reduced to moderate/light in 90% of patients in the IVIg group, [bolding added]

• Whereas no improvement was reported in the control group (P < 0.01).

In patients' quality of life, scores of the IVIg group (Short Form 36, Clinical Global Impression of Change, and Patient Global Impression of Change questionnaires) in all the follow-up were significantly higher than those of the control group (P < 0.01).

Conclusion: This unblinded pilot study showed a beneficial effect of IVIg on neuropathic pain intensity and quality of life in patients resistant to conventional treatments.

Source: Pain Medicine, Oct 2012;13(10) pp 1334-1341. DOI:10.1111/j.1526-4637.2012.01478.x, by Jann S, Francia A, Fruguglietti ME, De Toni Franceschini L, Sterzi R. Department of Neurology, Niguarda Hospital, Milan; Neurological Clinic, University La Sapienza, Rome, Italy.  [E-mail: stefano.jann@ospedaleniguarda.it]

___

1. Among the disorders that involve neuropathy are diabetes, chemotherapy damage, multiple sclerosis, shingles, spinal stenosis, peripheral artery disease, back/leg/hip problems, facial nerve problems, alcohol abuse, and more. Other studies have suggested that IVIg has the potential to reduce the pain of specific chronic painful conditions such as complex regional pain syndrome, and Sjogren’s syndrome.




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Protecting Our Eyes Against Time-Induced Damage Protecting Our Eyes Against Time-Induced Damage
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing