ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

CDC Whistleblower Reveals Widespread Manipulation of Scientific Data and Top-Down Pressure on CDC Sc...

How Glutathione Can Save Your Life

Reversing Neurodegeneration with a New Magnesium Compound

Coenzyme Q10 Benefits Symptoms in Gulf War Veterans: Results of a Randomized Double-Blind Study

Gut Bacteria, Artificial Sweeteners and Glucose Intolerance

Brain inflammation dramatically disrupts memory retrieval networks, UCI study finds

Scientists discover how to 'switch off' autoimmune diseases

Clinical trial demonstrates safety, effectiveness of immunotherapy for AdV, BKV, and herpesviruses i...

Surprising discovery: HIV hides in gut, evading eradication

New estrogen-based compound suppresses binge-like eating behavior in female mice

 
Print Page
Email Article

Is Chronic Fatigue Syndrome in Older Patients a different disease? – a clinical cohort study

  [ 9 votes ]   [ 2 Comments ]
www.ProHealth.com • February 13, 2013


Is Chronic Fatigue Syndrome in Older Patients a different disease? – a clinical cohort study

  –Source: Eur J Clin Invest, 2012

Abstract

Background: Chronic fatigue syndrome (CFS) is a disabling disorder characterised by persistent fatigue with a typical age of diagnosis of 35–50 years. CFS does present in those aged over 50 but whether this is a different disease in older age groups has not been considered. Therefore, we performed a clinical cohort study to examine and differentiate the clinical and autonomic features in CFS patients aged over 50.

Design: A total of 179 Fukuda diagnosed CFS patients were recruited, and 25 older CFS patients (50 + years) were matched case by case for gender and length of history to 25 younger CFS patients (16–29 years). A range of symptomatic-based questionnaires were used in addition to heart rate variability and baroreceptor sensitivity to assess autonomic function.

Results: Chronic fatigue syndrome can present for the first time in an older population. Older CFS patients demonstrate increased fatigue (Fatigue impact scale; 85 ± 33 vs. 107 ± 27, P = 0·02) (Chalder fatigue scale; 9 ± 3 vs. 11 ± 1, P = 0·002) and caseness for depression (Hospital Anxiety and Depression scale; 7 ± 3 vs. 10 ± 4; P = 0·005). There is a greater autonomic dysfunction in older CFS patients, with reduced parasympathetic function (HFnu; 49·1 ± 18 vs. 36·2 ± 18, P = 0·01, RR30 : 15; ± , P = 0·02) and increased sympathetic function (LFnu; 51·5 ± 17 vs. 63·8 ± 18, P = 0·01). Baroreflex sensitivity was substantially reduced (BRS; 19·7 ± 12 vs. 9·9 ± 5, P = 0·0004), and left ventricular ejection time prolonged (LVET; 274·6 ± 16 vs. 285·8 ± 9, P = 0·004).

Conclusions: Older CFS patients demonstrate a disease phenotype very different from younger patients. The combination of differing underlying pathogenic mechanisms and the physiological aspects of ageing result in a greater disease impact in older CFS patients.

Source: Eur J Clin Invest, 2012. Article first published online: 9 Feb 2013 [doi: 10.1111/eci.12046]. Ieuan Lewis, Institute for Ageing & Health, Newcastle University, Newcastle upon Tyne, UK; Jessie Pairman, Newcastle Hospitals NHS Foundation Trust, Northern CFS Clinical Network, Newcastle upon Tyne, UK; Gavin Spickett, Newcastle Hospitals NHS Foundation Trust, Northern CFS Clinical Network, Newcastle upon Tyne, UK; Julia L. Newton, Institute for Ageing & Health, Newcastle University, Newcastle upon Tyne, UK, Newcastle Hospitals NHS Foundation Trust, Northern CFS Clinical Network, Newcastle upon Tyne, UK NIHR Biomedical Research Centre in Ageing, Newcastle University, Newcastle upon Tyne, UK.




Please Discuss This Article:   Post a Comment 

Is this about CFS another name for ME or about psychiatry messing around
Posted by: simmons1
Feb 14, 2013
not to long ago back in the dark ages of my ME childhood children were claimed not to get ME instead school phobia was given as a reason for why children were believing themselves sick or Munchhausen by proxy were the mother was accused of creating ME in the minds of their children by psychiatrists . Now that i am getting older my ME is going to be put down to psychological problems due to old age a totally separate ME from my younger ME version of myself can i trust this research ,is it about old age or ME or is it just another psychological fix up job another spin to make ME the non disease lumped in with some sort of old age psychological theory to damage ME.
Reply Reply

I may have got this wrong
Posted by: simmons1
Feb 15, 2013
I may have jumped to conclusion here as I may have mistaken physiological aspects of aging as psychological aspects of aging I have also discovered that Gavin Spickett works in Immunology in Newcastle and this is an area that has an important part to play in researching ME .I apologize for being Hasty and harsh in my comment here it is very hard to determine what is going on in ME and should have checked my facts it is important that science looks into this illness .
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health

Natural Remedies

The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing