ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

New Lyme guidelines promote options and informed choice

Phases of clinical depression could affect treatment

“Worm pill” could ease autoimmune disease symptoms

Eating Baked or Broiled Fish Weekly Boosts Brain Health, Pitt Study Says

Preserving Cognitive Function with Aging

Scientists Look for Biomarkers to Improve Treatment of Painful Bladder Condition

9 Health Benefits of Cucumbers

New culprit identified in metabolic syndrome

Low vitamin D levels linked to increased risks after noncardiac surgery

Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel

 
Print Page
Email Article

Two-day Exercise Test Provides Objective Evidence for Post-Exertional Malaise in ME/CFS

  [ 26 votes ]   [ 1 Comment ]
By Christopher R. Snell et al. • www.ProHealth.com • July 8, 2013


Editor's Comment: Post-exertional malaise (PEM) is the hallmark symptom of ME/CFS. Dr. Christopher Snell's group has developed the 2-day Cardiopulmonary Exercise Test (CPET) for ME/CFS, a test that can objectively measure PEM. The CPET is a non-invasive test that has long been used to evaluate cardiac health. By measuring gas exchange (the ratio of oxygen to carbon dioxide), Snell's group has determined that, unlike controls, people with ME/CFS consistently show reduced oxygen consumption. This reseach supports other evidence demonstrating hypoxia (low oxygen levels) in the brains of patients with ME/CFS. It is important to note that the CDC study currently underway does not employ the 2-day CPET as described in this study, but the 1-day CPET, which does not measure PEM. The authors of this study have found the 1-day CPET to be inadequate for distinguishing ME/CFS patients from controls.

Discriminative Validity of Metabolic and Workload Measurements to Identify Individuals With Chronic Fatigue Syndrome

By Christopher R. Snell et al.

Abstract

Objectives:Reduced functional capacity and post-exertional fatigue following physical activity are hallmark symptoms of chronic fatigue syndrome (CFS) and may even qualify for biomarker status. That these symptoms are often delayed may explain the equivocal results for clinical cardiopulmonary exercise testing among individuals with CFS. Test reproducibility in healthy subjects is well documented. This may not be the case with CFS due to delayed recovery symptoms. The objectives for this study was to determine the discriminative validity of objective measurements obtained during CPET to distinguish individuals with CFS from non-disabled sedentary individuals.

Methods:Gas exchange data, workloads and related physiological parameters were compared between 51 individuals with CFS and 10 control subjects, all females, for two maximal exercise tests separated by 24 hours.

Results:Multivariate analysis showed no significant differences between controls and CFS for Test 1. However, for Test 2 the individuals with CFS achieved significantly lower values for oxygen consumption and workload at peak exercise and at the ventilatory/anaerobic threshold. Follow-up classification analysis differentiated between groups with an overall accuracy of 95.1%.

Conclusions:The lack of any significant differences between groups for the first exercise test would appear to support a deconditioning hypothesis for CFS symptoms. However, results from the second test indicate the presence of a CFS related post-exertional fatigue. It might be concluded that a single exercise test is insufficient to reliably demonstrate functional impairment in individuals with CFS. A second test may be necessary to document the atypical recovery response and protracted fatigue possibly unique to CFS, which can severely limit productivity in the home and workplace.

Source: Physical Therapy, 27 June 2013, doi: 10.2522/?ptj.20110368, Christopher R. Snell, Staci R. Stevens, Todd E. Davenport and J. Mark Van Ness. Contact: tdavenport@pacific.edu




Please Discuss This Article:   Post a Comment 

Two day test and PEM
Posted by: Coachme
Jul 19, 2013
The studies done by this group are major for CFS. It is a huge step forward in proving post-exertional malaise. I hope it will help many people with disability tests and help show the validity of this illness. I think it is also good to show that CFS problems with exercise are not deconditioning.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing