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Combined Exercise Therapy Improves Oxidative Stress in Fibromyalgia Patients

  [ 5 votes ]   [ 1 Comment ] • March 26, 2014

Effects of 12-week combined exercise therapy on oxidative stress in female fibromyalgia patients.

By Banu Sarifakioglu, et al.


The aims of this study were to investigate the effect of exercise therapy on the oxidative stress in fibromyalgia patients and relationship between oxidative stress and fibromyalgia symptoms.

Thirty women diagnosed with fibromyalgia according to the American College of Rheumatology preliminary criteria, and 23 healthy women whose age- and weight-matched women were enrolled the study. Pain intensity with visual analog scale (VAS), the number of tender points, the fibromyalgia impact questionnaire (FIQ), the Beck depression inventory (BDI) were evaluated. The oxidative stress parameters thiobarbituric acid reactive substances, protein carbonyls, and nitric oxide, and antioxidant parameters thiols and catalase were investigated in patients and control group.

After, combined aerobic and strengthen exercise regimen was given to fibromyalgia group. Exercise therapy consisted of a warming period of 10 min, aerobic exercises period of 20 min, muscle strengthening exercises for 20 min, and 10 min cooling down period. Therapy was lasting 1 h three times per week over a 12-week period.

All parameters were reevaluated after the treatment in the patient group. The oxidative stress parameters levels were significantly higher, and antioxidant parameters were significantly lower in patients with fibromyalgia than in the controls. VAS, FIQ, and BDI scores decreased significantly with exercise therapy.

The exercise improved all parameters of oxidative stress and antioxidant parameters. Also, all clinical parameters were improved with exercise. We should focus on oxidative stress in the treatment for fibromyalgia with the main objective of reducing oxidative load.

Source: Rheumatology International, March 9, 2014. By Banu Sarifakioglu, Aliye Yildirim Güzelant, Eda Çelik Güzel, Savas Güzel and Ali Riza Kiziler. Department of Physical Medicine and Rehabilitation, School of Medicine, Namik Kemal University, 100, Yil Mah, Barbaros Cad. Merkez, Tekirdag, Turkey.

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Article Comments Post a Comment

Posted by:
Mar 26, 2014
I notice this study had no mention of ME/CFS or what exercise could do to harm them. You read how the conditions often overlap. I hear about study after study but not the scientific methods added to be truly scientific. The study will often mention the number of participants but I have not seen any large numbers involved. I would like to know why we don't have the proper numbers of suffers for these studies? Are there only a few healthy FM suffers that they can find in the world?
With apparently millions of people seriously ill with ME/FM what is the hold up with a cure or even a cause? MONEY? Drug companies will make a load of profit if they can find a drug that might help.
I am just so disappointed with the dismissive treatment we have had for over thirty years or more. Do not forget we are dealing with mainly women. Is this why we are taking so long to get help? Would we have a cure if it happened mainly in men ...
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