ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Missing protein explains link between obesity, diabetes

The Brain Boosting and Fatigue Fighting B-12

Genetic basis for distinct type of autism uncovered

Unsuspected aspect of immune regulation revealed: Role of B cells

IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders

Explaining 'Healthy' Obesity

Sinus Congestion and Sinusitis, Healing Naturally

Ginger's Many Evidence-Based Health Benefits Revealed

Omega 3 Fatty Acids Lessen Severity of Osteoarthritis in Mice

In the gut, immunity is a two-way street

 
Print Page
Email Article

Disruption of circadian rhythms may contribute to inflammatory disease

  [ 6 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 27, 2014


Press Release: Rush University Medical Center via Eurekalert, May 21, 2014

A disruption of circadian rhythms, when combined with a high-fat, high-sugar diet, may contribute to inflammatory bowel disease and other harmful conditions, according to a recent study conducted by researchers at Rush University Medical Center. The study is online at the peer-reviewed, open-access journal, PLOS ONE.

"Circadian rhythms, which impose a 24-hour cycle on our bodies, are different from sleep patterns," said Robin M. Voigt, PhD, assistant professor at Rush Medical College and first author of the study. "Sleep is a consequence of circadian rhythms," Voigt said.

While circadian rhythm disruption may be common among some, the research suggests that it may be contributing to a host of diseases that may be prevented by regulating things such as sleep/wake patterns and times of eating to help prevent circadian rhythm disruption. Including prebiotics or probiotics in the diet can also help normalize the effects of circadian rhythm disruption on the intestinal microbiota to reduce the presence of inflammation.

"It's something that needs to be addressed -- not something people need to be very concerned about, but aware. If you have some of these other risk factors, like a high-fat, high-sugar diet," or a genetic tendency toward disruption in circadian rhythms, "take precautions, watch your diet, take pre- and probiotics, monitor your health, be vigilant," Voigt said.

The prevailing theory is that of a "second hit hypothesis" whereby individuals with at-risk lifestyle choices or genetic predispositions will only develop disease if a secondary insult is present. "We believe that chronic circadian rhythm disruption promotes/exacerbates inflammatory-mediated diseases, at least in part, due to changes in the intestinal microbiota," she said.

Inflammation is associated with a number of diseases, including cardiovascular disease and cancer, and can cause organ damage and is associated with increased morbidity and mortality.

In the study, male mice had their cycles of exposure to light and dark reversed on a weekly basis (i.e., "shifted"), an experience that is known to disrupt an organism's innate circadian rhythm. Some of the mice ate standard food; others ate a high-fat, high-sugar diet. Researchers found that the microbiota of the mice that had their circadian rhythms disrupted were significantly different from that of the control group -- but only if they had consumed the high-fat, high-sugar diet.

All the mice that ate the high-fat, high-sugar diet displayed changes in the makeup of the microorganisms in their guts, regardless of circadian status. However, mice that ate the high-fat, high-sugar diet, and had circadian-rhythm disruptions, had higher concentrations of bacteria that are known to promote inflammation than any of the other mice in the study. Disrupting the circadian rhythms of the mice fed standard chow did not significantly affect the microbiota in their intestines.

These findings support previous studies that have shown that the negative effects of circadian disruption are subtle enough that "a second environmental insult is often necessary to reveal [their] deleterious effects," the study says.

Many people have their circadian rhythms disrupted on a regular basis -- shift workers like nurses, doctors, firefighters and policemen. "Other people have 'social jet lag,' a lifestyle pattern that leads them to maintain a normal schedule on weekdays, but then stay up late and sleep in on the weekends," Voigt said.

"Looking forward, we would like to functionally evaluate how circadian rhythm disruption may influence diseases including colon cancer, which may in part be the consequence of altered intestinal microbiota," she concluded.

Journal Reference: Robin M. Voigt, Christopher B. Forsyth, Stefan J. Green, Ece Mutlu, Phillip Engen, Martha H. Vitaterna, Fred W. Turek, Ali Keshavarzian. Circadian Disorganization Alters Intestinal Microbiota. PLoS ONE, 2014; 9 (5): e97500 DOI: 10.1371/journal.pone.0097500



Discuss This Article Post a Comment 




[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products

Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid

Natural Remedies

The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
A Breakthrough for Mitochondrial Dysfunction A Breakthrough for Mitochondrial Dysfunction
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing