ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

Print Page
Email Article

Scientists discover the role of T cells in bone destruction

  [ 581 votes ]   [ Discuss This Article ]
By Staff • • November 18, 1999

The role of T cells in the crippling bone and cartilage deterioration characteristic of many diseases including arthritis and other inflammatory diseases has been unraveled for the first time by a research team at Princess Margaret Hospital and the AMGEN Research Institute.

Inflammation can trigger the body's T cells to inadvertently cannibalize its own bone, leading to severe bone degeneration and debilitating pain.

The finding paves the way for future research into preventing the onset and progression of bone erosion in arthritis and the prevention of osteoporosis associated with many different kinds of diseases. The findings are reported in the November 18, 1999 issue of the journal Nature. The research was funded by the AMGEN Research Institute.

The research marks the first time in the world that a research team has clearly identified the molecular cause of the bone and cartilage deterioration characteristic of many inflammatory diseases. Lead author Dr. Josef Penninger, an immunologist at Princess Margaret Hospital and the AMGEN Institute, and a member of the Departments of Medical Biophysics and Immunology at the University of Toronto said, "When I realized what we had found, I was stunned. This could be the seminal paper for the prevention and treatment of bone loss in arthritis, and perhaps even for the treatment of bone loss in leukemia, hepatitis, HIV/AIDS, diabetes, multiple sclerosis, lupus and other diseases associated with inflammation and bone loss."

The research was a collaborative effort between Dr. Penninger and his colleague Dr. Young-Yun Kong in Toronto, and Drs. Ulrich Feige and Bill Boyle at AMGEN in Thousand Oaks, California.

Earlier this year, Drs. Penninger, Kong and Boyle discovered OPGL, a gene that triggers the body's cells to cannibalize its own bone, leading to severe osteoporosis. They also discovered that the same gene regulates the development of lymph nodes and white blood cells, the body's protection against infection. "We were puzzled by our finding that certain white blood cells, called T cells, produce a substance that triggers bone loss ," said Dr. Penninger. "We set out to find out why T cells make OPGL. What we uncovered is a molecular trigger for bone destruction in many diseases such as arthritis and even cancer."

Cells Become Cannibals: The infantry of the body's immune system, T cells spend most of their lives waiting to fight off offending disease. When the body is attacked by a virus or bacteria, T cells are "turned on" and begin producing OPGL, causing local or systemic bone loss.

Diseases which cause inflammation, such as arthritis, hepatitis, AIDS and many others attract T cells, which arrive at the sight of the inflammation ready to fight. When they head into battle, T cells produce OPGL. "The production of OPGL probably allows our T cells to activate the development of other blood cells required to fight off infection," said Dr. Penninger. "Unfortunately in chronic viral infections, autoimmune diseases and some cancers, T cells do not stop their attack, causing the OPGL-producing T cells to seek out and destroy the body's own bone and cartilage."

"Many patients who suffer from chronic viral infections, infectious diseases, allergic conditions, autoimmune disorders or various forms of cancer experience mild or severe bone and cartilage loss," said Dr. Kong. "Until now, we never knew why or what the connection was. Now we know that diseases, which cause inflammation in the body and activate the immune system initiate a T cell attack, also triggering an attack against the bones. Now that we know what is causing that bone loss, we can stop it."

On the heels of successful experiments in rats, a natural blocker of OPGL is currently in phase I human clinical trials in the United States. If the trials are successful, testing of the OPGL blocker may begin in patients with osteoporosis, metastatic bone disease or rheumatoid arthritis.

In human studies, Dr. Penninger and his research team found that, without exception, 100 percent of all osteoarthritis and rheumatoid arthritis patients they examined expressed OPGL in their joints, making the correlation absolute. "Arthritis patients suffer from severe destruction of the bone surrounding their joints, causing irreversible damage to the joints, pain and permanent physical disabilities," said Dr Penninger.

"When arthritic rats are injected with the OPGL inhibitor or blocker at the first sign of inflammation, bone loss and cartilage destruction stops completely. OPGL inhibition may also be the future treatment of choice to block the crippling bone loss associated with cancer or hepatitis."

Arthritis exists in over 100 forms and is responsible for disabling over 600,000 Canadians and affecting more than four million people, including men, women and children. The USA alone spends over $50 billion a year to treat arthritis and related diseases. Forms of arthritis include tendinitis, bursitis, fibromyalgia, lupus, rheumatoid and osteoarthritis. The common denominator of all forms of the disease is joint and musculoskeletal pain and bone loss and ultimately life-long crippling as a result of inflammation of the joint lining.

Princess Margaret Hospital, a teaching hospital of the University of Toronto, has achieved an international reputation as a global leader in the fight against cancer and is considered one of the top comprehensive cancer research and treatment centres in the world. PMH is a member of the University Health Network, which also includes Toronto General Hospital and Toronto Western Hospital.

The AMGEN Research Institute is an integral part of AMGEN, the world's largest biotechnology company and an innovative and pioneering world-wide organization dedicated to the research and development, manufacture and marketing of human proteins for therapeutic use, using recombinant DNA technology.

Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Complete and Natural Menopause Relief Complete and Natural Menopause Relief
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map