ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Calorie restriction promotes longevity through effects on mitochondrial network

Discover Why Ashwagandha Can Be Used for Stress and Anxiety

How Can You Benefit From Vitamin B12?

A spoonful of oil: Fats and oils help to unlock full nutritional benefits of veggies, study suggests

Lower magnesium levels linked with increased mortality risk during up to 40 years of follow-up

Higher resveratrol dose linked to lower glucose levels in type 2 diabetics

What Is Bitter Orange?

Drug can dramatically reduce weight of people with obesity

New Finding: Broccoli Helps Heal Leaky Gut

Tryptophan's Possible Effects for Your Health

 
Print Page
Email Article

Cytokine Signal Shuts Down Hyperactive T Cells; “Off Switch” Could Halt Inflammation And Autoimmunity

  [ 49 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 25, 2003


November 25, 2003

PHILADELPHIA -- Since their discovery, cytokines have provided biomedical researchers with a tangled web of immune-system pathways to unknot. While most known cytokines have a role in stimulating immunity, one cytokine, IL-27, may actually suppress CD4 T cells, the helper T cells that orchestrate the immune system response to infections, according to researchers at the University of Pennsylvania School of Veterinary Medicine.

Their findings could provide researchers with a way to clamp down on dozens of autoimmune conditions caused by an overzealous immune system, such as Crohn disease, lupus or even sepsis. Their research is the cover article for the November issue of the journal Immunity.

"When the immune system is activated there is a cascade of cytokine interactions that regulate the growth and functions of an array of immune cells," said Christopher Hunter, an associate professor in Penn Department of Pathobiology and senior author of the paper. "Contrary to previous studies, the IL-27 cytokine actually limits the duration and intensity of T cell activation, an 'off switch' as it were."

To gauge the function of IL-27, Hunter and his colleagues used mice that lack the cytokine receptor, a protein called WSX-1. Without WSX-1, IL-27 lacked a target a button to press and the researchers were able to determine how the immune system worked without this particular cytokine.

When the animal models were challenged with a toxoplasma infection, their immune systems were able to fight off the parasite but their immune response continued well after the parasites were controlled. Instead, the researchers found a surplus of activated T cells and increasing amounts of interferon gamma, a cytokine that activates antigen-presenting cells and other parts of the immune system.

These results differed from previous studies that showed IL-27 to be among the many cytokines involved in T cell differentiation and growth. Despite its similarity to other T cell-promoting cytokines, IL-27 and its receptor may be an important part of the regulation of the immune system.

According to the researchers, the identification of the role of IL-27 and its receptor has obvious clinical implications for autoimmune disorders involving T cell mediated inflammatory responses. Autoimmune diseases, while varying in severity, result as immune cells primed and activated begin destroying native cells as well as those of pathogens.

"There are many immune-mediated diseases with many different causes, but this particular pathway may represent a universal checkpoint for the immune system," Hunter said. "It may be possible to create drugs that turn the immune system off without actually suppressing the beneficial immune reactions."

Funding for this research was supported by grants from the National Institutes of Health.

Other Penn scientists involved in this study were Alejandro Villarino, Linda Lieberman and Emma Wilson. Linda Hibbert and Robert Kastelein of DNAX Research Institute, Tak Mak of the University of Toronto, Hiroki Yoshida of Kyushu University and Christiaan Saris of Amgen Inc. also contributed to the Immunity paper.



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida® Ultra ATP+, Double Strength


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
Safely Burn Away Body Fat Safely Burn Away Body Fat
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
Natural Bladder Control, Go Less and Live More Natural Bladder Control, Go Less and Live More

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map