ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

Print Page
Email Article

Increased Free Radical Levels May Cause Fibromyalgia

  [ 751 votes ]   [ Discuss This Article ] • January 19, 2004

A DGReview of: "Free radicals and antioxidants in primary fibromyalgia: an oxidative stress disorder?"

Rheumatology International


By Mary Beth Nierengarten

Fibromyalgia may be an oxidative disorder as indicated by the increased levels of malondialdehyde (MDA) and decreased levels of superoxide dismutase (SOD) in patients with this disease, reports a study from Turkey.

Although the aetiology of fibromyalgia remains unknown, recent data suggest that the oxidant/antioxidant balance may play a role in its development.

Based on the hypothesis that a balance discordance in the oxidant/antioxidant status may indicate that fibromyalgia is an oxidative disorder, Selda Bagis, MD, Mersin University Medical School, and colleagues compared the oxidant/antioxidant status of 85 women with primary fibromyalgia to that of 80 healthy, age-, weight-, and height-matched women. Along with evaluation of sex hormone profiles and routine blood, sedimentation, thyroid, C-reactive, liver, and kidney function tests, body mass index (BMI), smoking, and duration of disease were also documented for all patients. Pain was evaluated using the visual analog scale (VAS) and the presence and number of tender points were recorded. Assessment of the oxidant/antioxidant status was based on measuring MDA, which is a marker of free radical damage, and SOD, which shows antioxidant capacity.

In patients with fibromyalgia, MDA levels were significantly higher (P = .000) and SOD levels significantly lower (P = .000) than in the control patients. Number of tender points and VAS were not significantly associated with MDA or SOD (P > .05), and no correlation was found between BMI, age, duration of disease and MDA or SOD (P > .05).

These data suggest, claim the authors, that the "oxidant/antioxidant imbalance related to the disease process, and the increase in free radical levels may be responsible for the development of fibromyalgia."

The authors conclude that these data support their hypothesis that fibromyalgia is an oxidative disorder, and that additional larger studies are needed for validation.

Rheumatol Int 2003 Dec 20;[Epub ahead of print]. "Free radicals and antioxidants in primary fibromyalgia: an oxidative stress disorder?"

Source: Doctor’s Guide (DG) online. (C) Doctor's Guide, online at

Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
Thyroid Health and Fibromyalgia Thyroid Health and Fibromyalgia
The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS
Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map