ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Curcumin: The All In One Solution, Part 2

CoQ10 — A Nutritional Powerhouse for Mitochondrial Health

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Use Burdock Oil to Promote Healthy Hair Growth

Why You Should Take Your Apple Cider Vinegar at Night

AMA journal associates iron deficiency with hearing loss

Lutein linked to preservation of crystallized intelligence

Zinc eaten at levels found in biofortified crops reduces 'wear and tear' on DNA

A handful of nuts a day cuts the risk of a wide range of diseases

 
Print Page
Email Article

As Testing Campaigns Identify More People With Asymptomatic Hepatitis C Infection, Benefits, Risks and Cost-Effectiveness of Early Treatment Uncertain

  [ 59 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 9, 2004


Women, those infected at young age, certain virus subtypes may not see great benefit from early therapy For immediate release: Tuesday, July 8, 2003 Boston, MA - In the first analysis that takes into account the variety in progression of hepatitis C infection, researchers at Harvard School of Public Health’s Center for Risk Analysis looking at the clinical benefit and cost effectiveness of the latest treatment for the disease have concluded that early treatment may not be the right choice for many thousands of people with asymptomatic hepatitis C infection. Their analysis is described in the July 9, 2003 issue of the Journal of the American Medical Association (JAMA) “Cost-Effectiveness of Treatment for Chronic Hepatitis C Infection in an Evolving Patient Population.” Hepatitis C virus (HCV) is a largely asymptomatic disease that after a long latency period, usually spanning decades, can damage the liver and eventually cause cirrhosis and liver cancer. While it is currently a leading cause of liver transplantation in the U.S., many infected patients will never develop advanced liver disease. HCV infection is most commonly transmitted through shared needle use and also had been passed along through blood transfusions before testing of blood donations largely eliminated that route in the early 1990s. The current treatment recommended for HCV is an injected long-acting interferon plus oral ribavarin. Treatment has improved considerably in the last decade but is still only effective in 40 to 60 percent of patients, has potentially severe side effects (e.g., nausea, severe fatigue, depression and, in some cases, suicidal impulses), and a single 48-week treatment course costs more than $20,000. Previous analyses have found that treating HCV is clinically beneficial and cost-effective, on average, in patients infected with HCV and with evidence of existing liver disease. For patients without evidence of liver damage, the effects of early therapy on life expectancy and particularly on patient quality of life are less clear. In the United States an estimated 2.7 million individuals are chronically infected with HCV, but many of these people remain unaware of their infections. Rising interest in HCV from patient advocacy groups, public health advisory groups, and the lay press has been accompanied by a range of policy initiatives such as a government ‘lookback’ campaign launched in 1998 to notify people who received blood from potentially infected donors and an open letter from the Surgeon General in July 2000 warning the public about the ‘silent epidemic’ and encouraging at-risk individuals to get tested. In this analysis, HSPH researchers, led by Joshua Salomon, assistant professor of international health, looked at a patient population of HCV seropositive but otherwise healthy individuals-- people with the mildest form of the disease and the group most likely to be turned up in larger numbers by the HCV testing campaigns. Additionally, the researchers examined the latest information on the progression of the disease in several subgroups of patient by gender, age and other factors. This data showed that progression is highly variable, and some 30 to 70 percent of infected individuals may never progress to liver cirrhosis before dying from other causes. In women in particular HCV appears to progress especially slowly. The probability of developing cirrhosis during a 30-year period was estimated to be between 13 and 46 percent for men and between one and 29 percent for women. Progression rates to cirrhosis and its complications are probably also substantially lower among those individuals infected at relatively young ages. “Taking into account this lowered assessment of risk for some groups, the possible toxic side effects of therapy, and the limited efficacy of current regimens, the benefits of early therapy may not outweigh the substantial costs and decreases in quality of life for some individuals,” said Sue Goldie, associate professor of health decision science and senior author of the paper. “As the pool of patients eligible for treatment expands to the more general population, it will be imperative for patients and their physicians to consider these factors in approaching treatment decisions at the individual level.” “Policy makers need to carefully consider the implications that public health campaigns targeted at HCV will have on the individual clinical decisions that follow,” said Salomon. “There has been a huge effort over the last few years to identify people infected with HCV, but this wider group of patients will likely include those who are least likely to develop advanced liver disease. For patients at low risk of progressing, the overall health gain from treatment may be minimal given the potential for toxic side effects.” The research was supported in part by a grant to Dr. Salomon from the former Agency for Health Care Policy and Research. Coauthors Drs. Goldie, Milton Weinstein and James Hammitt are members of the Harvard Center for Risk Analysis and the Department of Health Policy and Management at HSPH. For further information, please contact: Robin Herman
Director of Communications
Harvard School of Public Health
677 Huntington Avenue
Email: rherman@hsph.harvard.edu



Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Optimized Curcumin Longvida® Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Vital Molecule Increases Cellular Energy and Improves Cognitive Function Vital Molecule Increases Cellular Energy and Improves Cognitive Function
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
Live Without Anxiety or Stress Live Without Anxiety or Stress
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map