ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Curcumin: The All In One Solution, Part 2

CoQ10 — A Nutritional Powerhouse for Mitochondrial Health

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Use Burdock Oil to Promote Healthy Hair Growth

Why You Should Take Your Apple Cider Vinegar at Night

AMA journal associates iron deficiency with hearing loss

Lutein linked to preservation of crystallized intelligence

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

Zinc eaten at levels found in biofortified crops reduces 'wear and tear' on DNA

 
Print Page
Email Article

New TNF-Alpha Inhibitor for Rheumatoid Arthritis

  [ 11 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 27, 2002




Isis Pharmaceuticals, Inc. announced it has initiated a Phase II clinical trial of ISIS 104838, an inhibitor of tumor necrosis factor-alpha (TNF-alpha), in rheumatoid arthritis (RA).

The Phase II clinical trial will evaluate the safety and efficacy of ISIS in RA when administered by subcutaneous injection (SQ) for three months. This is the second Phase II study of ISIS currently in progress.

TNF-alpha is a naturally occurring cytokine that is involved in the development and progression of many inflammatory diseases, including RA. The double-masked, placebo-controlled, randomized Phase II study is planned to enroll 160 people with RA at 25 sites in the U.S. and Canada.

Three dosing regimens will be examined in this study: ISIS injections twice a week, once a week or once every other week. The primary endpoint in the study is improvement in American College of Rheumatology (ACR) response criteria, which measures improvement in patient and professional reported disease severity and activity.

"We are pleased to begin the second study of ISIS in people with rheumatoid arthritis, and to move forward with the clinical development of our new generation of antisense drugs. The initial Phase II trial, which began last November, is studying ISIS drug concentrations in tissue and blood as well as the drug's ability to reduce TNF-alpha levels. This new trial will be the first to provide efficacy information about ISIS in RA. We will use the combined results from the two studies to direct our future development plans with this drug," said F. Andrew Dorr, M.D., Isis Vice President and Chief Medical Officer.

Isis' first Phase II clinical trial of ISIS is evaluating the biological effect of TNF-alpha inhibition by ISIS in 20 RA patients over a four-week treatment period.

Phase I trials of intravenous infusion and SQ administration of ISIS demonstrated enhanced tolerability, duration of effect and dosing convenience compared with first-generation drugs.





Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Ultra EPA  - Fish Oil Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep? Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep?
Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map