ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Relief for IBS, Colitis, Crohn’s And More

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Restless Leg Syndrome (RLS) - are you running a marathon each night?

Can Magnesium Relieve Your Tinnitus?

Resveratrol Proven to Slow Brain Aging

Cassia Bark Oil: Why It's Valuable in Traditional Chinese Medicine

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Prenatal vitamin D could help prevent autism in children

Magnesium Protects Against Stroke, Heart Disease and Diabetes

 
Print Page
Email Article

Brain Pathway Shows Potential Therapy for Chronic Pain Including Fibromyalgia

  [ 239 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 11, 2004


A pain-signaling pathway in the brain, modulated by the neurotransmitter GABA-B, could be the source of a potential therapy for controlling chronic pain, according to a recent study partly funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). The study by Luc Jasmin, M.D., of the University of California, San Francisco and his colleagues from Harvard Medical School and Catholic University (Milan, Italy), looked at two pain-signaling pathways in animal models: communication between the RAIC (rostral agranular insular cortex, a small region of the cerebral cortex) and the amygdala (a brain area involved in pain, fear and attention), and between the RAIC and the locus coeruleus (an area involved in inhibiting pain signals from the brain to the rest of the body). Their work showed that signals from the RAIC to the amygdala--inhibited by GABA-B --might be involved in chronic pain. When the RAIC sends signals to the amygdala, pain is experienced; equally, communication between the RAIC and the locus coeruleus increases pain. Therefore, increasing GABA-B in the RAIC silences the pathway to the amygdala or the locus and decreases pain. Making matters more complicated, both signaling pathways act independently, and the one to the amygdala predominates. One can first decrease pain by blocking the pathway to the locus coeruleus and then increase pain by activating the pathway to the amygdala. Anesthetizing the amygdala then restores the initial condition of pain inhibition. The RAIC employs two different GABA receptors--GABA-A and GABA-B--to communicate with the locus coeruleus and the amygdala, respectively. It might be possible, say the scientists, to inhibit the signals from the RAIC to the amygdala by manipulating GABA-B receptors in the cerebral cortex. This might benefit patients who experience chronic pain. Most current therapies work "from the bottom up," focusing on peripheral areas where the pain is experienced. This research points toward an approach "from the top down": blocking the signals from the brain to the peripheral areas affected by pain. Chronic pain is a debilitating feature of fibromyalgia and other rheumatic diseases of concern to the NIAMS. The National Institute of Neurological Disorders and Stroke (NINDS) also provided support for the study. NIAMS and NINDS are part of the National Institutes of Health within the Department of Health and Human Services. The study was published in the July 17, 2003, issue of Nature. Study reference: Jasmin L, Rabkin SD, Granato A, Boudah A, Ohara PT. Analgesia and hyperalgesia from GABA-mediated modulation of the cerebral cortex. Nature 2003; 424 (6946): 316-20. Source: National Institute of Arthritis and Musculoskeletal and Skin Diseases. Online at www.niams.nih.gov.



Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Vital Molecule Increases Cellular Energy and Improves Cognitive Function Vital Molecule Increases Cellular Energy and Improves Cognitive Function
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map